T 98475 is a potent, non-peptide gonadotropin-releasing hormone (GnRH) receptor antagonist. The IC50 values are 0.2, 4.0, and 60 nM for human, monkey, and rat GnRH receptors, respectively. T 98475 also inhibits the release of LH in vitro (IC50 = 100 nM).
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2. Sasaki, Satoshi., et al., 2003. Discovery of a thieno[2,3-d]pyrimidine-2,4-dione bearing a p-methoxyureidophenyl moiety at the 6-position: a highly potent and orally bioavailable non-peptide antagonist for the human luteinizing hormone-releasing hormone receptor. Journal of medicinal chemistry. 46(1): 113-24. PMID: 12502365
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