Syntide-2, Protein Kinase SubstrateA peptide substrate of protein kinase enzymes

Syntide-2, Protein Kinase Substrate (CAS 108334-68-5)

Syntide-2, Protein Kinase Substrate | CAS 108334-68-5 is rated 5.0 out of 5 by 1.
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Synonym: Pro-leu-ala-arg-thr-leu-ser-val-ala-gly-leu-pro-gly-lys-lys
Application: A peptide substrate of protein kinase enzymes
CAS Number: 108334-68-5
Purity: >97%
Molecular Weight: 1507.82
Molecular Formula: C68H122N20O18
* Refer to Certificate of Analysis for lot specific data (including water content).
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Syntide-2 Protein Kinase Substrate is a synthetic peptide recognized as a substrate by CaMKII (Ca2+/calmodulin-dependent protein kinase II) enzymes. The sequence of Syntide-2 is homologous to phosphorylation site 2 on glycogen synthase, a target of CaMKII action. Syntide-2 has been used as a probe to assay localization of CaMKII activity and to study the effects of point mutations on phosphorylation activity. Numerous kinase enzymes including CaMKV and Raf-1 are reported to recognize Syntide-2 as a substrate as well, suggesting a wide scope of Syntide-2-assayable systems. Syntide-2, Protein Kinase Substrate is a substrate of Raf-1and PKC.


References

1. Hashimoto, Y., et al. 1987. Arch. Biochem. Biophys. 252: 418-425. PMID: 3028265
2. Li, P., et al. 1991. Cell. 64: 479-482. PMID: 1846778
3. Mochizuki, H., et al. 1993. J. Biol. Chem. 268: 9143-9147. PMID: 8386178
4. Ishida, A. and Fujisawa, H. 1995. J. Biol. Chem. 270: 2163-2170. PMID: 7836445

Formulation :
TFA salt
Physical State :
Solid
Solubility :
Soluble in water, and 1% acetic acid (1 mg/ml).
Storage :
Store at -20° C
Density :
1.41 g/cm3
Refractive Index :
n20D 1.63
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
5748289
MDL Number :
MFCD00076727
SMILES :
CC(C)CC(C(=O)NC(C)C(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)O)C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(C(C)C)C(=O)NC(C)C(=O)NCC(=O)NC(CC(C)C)C(=O)N1CCCC1C(=O)NCC(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)O)NC(=O)C2CCCN2

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Various publications have cited the use of Syntide Various publications have cited the use of Syntide-2, Protein Kinase Substrate as a probe to assay localization of CaMKII activity and to study the effects of point mutations on phosphorylation activity. -SCBT Publication Review
Date published: 2015-05-17
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