Synthalin sulfateAn NMDA receptor antagonist

Synthalin sulfate (CAS 111-23-9)

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Synonym: N,N'-1,10-Decanediyl-bis(guanidine) sulfate
Application: An NMDA receptor antagonist
CAS Number: 111-23-9
Purity: 99%
Molecular Weight: 354.5
Molecular Formula: C12H28N6•H2SO4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Synthalin sulfate is a competitive antagonist of the NMDA (N-methyl-D-aspartate) receptor polyamine site. The compound reduces proton inhibition of isolated NMDA (N-methyl-D-aspartate) channels and may have more that one binding site. Data shows that polyamines have been found to reduce proton inhibition of isolated NMDA (N-methyl-D-aspartate) channels in vitro.


References

1. Reynolds, I.J., et al. 1991. J. Pharmacol. Exp. Ther. 259: 626-632. PMID: 1658306
2. Reynolds, I.J. 1992. J. Pharmacol. Exp. Ther. 263: 632-638. PMID: 1432693
3. Hackman, J.C., et al. 2010. Brain Res. 1325: 10-18. PMID: 20156426

Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Soluble in water (20 mg/ml).
Storage :
Store at -20° C
Melting Point :
233° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
44134960
EC Number :
203-848-1
SMILES :
C(CCCCCN=C(N)N)CCCCN=C(N)N.OS(=O)(=O)O

Download SDS (MSDS)

Certificate of Analysis

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