SW033291A small-molecule inhibitor of 15-PGDH

SW033291 (CAS 459147-39-8)

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Synonym: 2-(butylsulfinyl)-4-phenyl-6-(2-thienyl)-thieno[2,3-b]pyridine-3-amine; SW 033291; SW-03329; SW 033291
Application: A small-molecule inhibitor of 15-PGDH
CAS Number: 459147-39-8
Molecular Weight: 412.6
Molecular Formula: C21H20N2OS3
* Refer to Certificate of Analysis for lot specific data (including water content).
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SW033291 is a chemical inhibitor that has been shown to increase prostaglandin PGE2 levels in vitro which was shown to effect the liver, bones, tissues, and cancer cells in vitro. SW033291 is an inhibitor of of the enzyme 15-hydroxy prostaglandin dehydrogenase, which initiates the catabolism of PGs and related eicosanoids. SW033291 promotes tissue regeneration in mouse models of colon and liver injury, and accelerates hematopoietic recovery in mice receiving a bone marrow transplant.

Physical State :
Solid
Solubility :
Soluble in ethanol (~3 mg/ml), DMSO (~30 mg/ml), DMF (~30 mg/ml), and aqueous buffers (sparingly).
Storage :
Store at -20° C
Melting Point :
275.08° C (Predicted)
Boiling Point :
~670.1° C at 760 mmHg (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.74 (Predicted)
Ki Data :
PGDH: Ki= ~0.1 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
3337839
SMILES :
CCCCS(=O)C1=C(C2=C(S1)N=C(C=C2C3=CC=CC=C3)C4=CC=CS4)N

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Certificate of Analysis

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Hace 23 años sufrí un accidente de tránsito que me dejó con sonda de cistostomía. Esta droga puede regenerar los tejidos de mi Uretra?

Asked by: Mauricio53
Gracias por su pregunta. Nuestros productos son unicamente para realizar investigaciones cientificas o ser usados en un laboratorio. Estos productos no pueden ser administrados en humanos o para diagnosticar enfermedades. Thank you for your question. Our products are for research or laboratory use only and are not to be administered to humans or used for medical diagnostics.
Answered by: Technical Support
Date published: 2018-12-06
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