SUN-B 8155A selective calcitonin receptor agonist

SUN-B 8155 (CAS 345893-91-6)

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Synonym: 5-[1-[(2-Aminophenyl)imino]ethyl]-1,6-dihydroxy-4-methyl-2(1H)-pyridinone
Application: A selective calcitonin receptor agonist
CAS Number: 345893-91-6
Purity: ≥97%
Molecular Weight: 273.29
Molecular Formula: C14H15N3O3
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* Refer to Certificate of Analysis for lot specific data (including water content).
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SUN-B 8155 is a pyridone derivative with biological activity similar to that of calcitonin (CT), a polypeptide hormone involved in regulating blood calcium levels. Like CT, SUN-B 8155 has been shown to elevate cyclic AMP levels in cells and is estimated to interact with the CT receptor by a mechanism similar to that of CT itself. SUN-B 8155 is an activator of CT-R.


References

1. Katayama, T., et al. 2001. Biochim. Biophys. Acta 1526: 183-190.

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM).
Storage :
Store at 4° C
Refractive Index :
n20D 1.64 (Predicted)
IC50 :
Stimulation of cAMP production: EC5050 = 21 µM (CHO/hCTR cells )
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
16079007
MDL Number :
MFCD08276926
SMILES :
CC\\1=CC(=O)N(C(=O)/C1=C(/C)\\NC2=CC=CC=C2N)O

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Certificate of Analysis

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