SulochrinCAS: 519-57-3
MF: C17H16O7
MW: 332.3
An inhibitor of the degranulation, activation and chemotaxis of eosinophils.

Sulochrin (CAS 519-57-3)

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Application: An inhibitor of the degranulation, activation and chemotaxis of eosinophils
CAS Number: 519-57-3
Purity: >99%
Molecular Weight: 332.3
Molecular Formula: C17H16O7
* Refer to Certificate of Analysis for lot specific data (including water content).
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Sulochrin is a fungal metabolite isolated from both Penicillium sp. and Asperigillus, described to inhibit the degranulation, activation and chemotaxis of eosinophils. Additionally, Sulochrin has been shown to inhibit eosinophil O2 and IL-8 production, and LTC4 release. Studies suggest that Sulochrin inhibits the tube formation of HUVECs induced by the vascular endothelial growth factor (VEGF). Data from Aspergillus terreus lovastatin studies report Sulochrin as a co-metabolite during its fermentation.


References

1. Ohashi, H., et al. 1997. J. Antibiot. 50: 972-974. PMID: 9592574
2. Ohashi, H., et al. 1998. Inflamm. Res. 47: 409-415. PMID: 9831326
3. Ohashi, H., et al. 1999. Bioorg. Med. Chem. Lett. 9: 1945-1948. PMID: 10450959
4. Lee, H.J., et al. 2002. J. Antibiot. 55: 552-556. PMID: 12195960
5. Couch, R.D. and Gaucher, G.M. 2004. J. Biotechnol. 108: 171-178. PMID: 15129726

Physical State :
Solid
Derived From :
Aspergillus terreus
Solubility :
Soluble in ethanol, methanol, DMF or DMSO
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
160505
MDL Number :
MFCD07370145
SMILES :
COC(=O)C1=CC(O)=CC(OC)=C1C(=O)C1=C(O)C=C(C)C=C1O

Download SDS (MSDS)

Certificate of Analysis

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