Sulindac SulfoneAn inhibitor of growth and inducer of apoptosis in cancer cell lines

Sulindac Sulfone (CAS 59864-04-9)

Sulindac Sulfone | CAS 59864-04-9 is rated 5.0 out of 5 by 1.
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Synonym: Exisulind; Aptosyn; Prevatec
Application: An inhibitor of growth and inducer of apoptosis in cancer cell lines
CAS Number: 59864-04-9
Purity: ≥96%
Molecular Weight: 372.41
Molecular Formula: C20H17FO4S
* Refer to Certificate of Analysis for lot specific data (including water content).
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Sulindac Sulfone is a metabolite of Sulindac (sc-202823) which inhibits cell growth and induces apoptosis in human cancer cell lines. It does not, however, inhibit cyclooxygenase (Cox).


References

1. Taylor, M.T., et al. 2000. Cancer Res. 60: 6607-6610. PMID: 11118042
2. Soh, J.W., et al. 2000. Clin. Cancer Res. 6: 4136-4141. PMID: 11051267
3. Myers, C., et al. 2001. Urology. 57: 73-76. PMID: 11295599
4. Skopinski, P., et al. 2004. Int. J. Mol. Med. 14: 707-711. PMID: 15375605
5. Sauter, A., et al. 2010. Anticancer Res. 30: 339-343. PMID: 20332437

Physical State :
Solid
Solubility :
Soluble in DMSO (>25 mg/ml), ethanol (warm) (3 mg/ml), acetone (5 mg (plus 0.1 ml)), and chloroform.
Storage :
Store at room temperature
Melting Point :
201-203° C
Boiling Point :
~601.9° C at 760 mmHg (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.62
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
5472495
MDL Number :
MFCD01317811
SMILES :
CC\\1=C(C2=C(/C1=C\\C3=CC=C(C=C3)S(=O)(=O)C)C=CC(=C2)F)CC(=O)O

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Certificate of Analysis

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Sulindac Sulfone  Product Citations

See how others have used Sulindac Sulfone. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 10910034  Thompson, WJ. et al. 2000. Cancer Res. 60: 3338-3342.

PMID: # 11051267  2000. Clin Cancer Res. 10: 4136-4141.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Soh Soh, et. al. (PubMed ID 11051267) concluded that sulindac sulfone and other sulindac derivaties induce apoptosis via the activationof the PKG protein (at least partially). -SCBT Publication Review
Date published: 2015-03-09
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