Sulindac CAS: 38194-50-2
MF: C20H17FO3S
MW: 356.41
An inhibitor of the NF-κB pathway and a Cox inhibitor.

Sulindac (CAS 38194-50-2)

Sulindac | CAS 38194-50-2 is rated 5.0 out of 5 by 1.
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Alternate Names: MK-231; (1Z)-5-Fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic acid; cis-5-Fluoro-2-methyl-1-[p-(methylsulfinyl)benzylidene]-indene-3-acetic acid
Application: Sulindac is an inhibitor of the NF-κB pathway and a Cox inhibitor
CAS Number: 38194-50-2
Purity: ≥98%
Molecular Weight: 356.41
Molecular Formula: C20H17FO3S
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Sulindac inhibits the NF-κB pathway. Sulindac is a non-steroidal anti-inflammatory drug. Sulindac reduces the level and activity of several cyclin-dependent kinases (CDKs) and induces apoptosis. Sulindac metabolizes to sulindac sulfide (sc-200118), a Cox (cyclooxygenase) inhibitor that represses ras signaling, and sulindac sulfone (sc-200120), an antitumor agent. Sulindac is an inhibitor of Cox-1 and Cox-2.


References

1. Shen, T.Y. and Winter, C.A. 1977. Adv. Drug Res. 12: 290- 245. PMID: 343530
2. Taylor, M.T., et al. 2000. Cancer Res. 60: 6607-6610. PMID: 11118042
3. Haanen, C. 2001. Curr. Opin. Invest. Drugs. 2: 677-683. PMID: 11569947

Physical State :
Solid
Solubility :
Soluble in water (0.05 mg/ml at 25° C), methanol (50 mg/ml), ethanol (9 mg/ml at 25° C), DMSO (71 mg/ml at 25° C), and DMF (~ 30 mg/ml).
Storage :
Store at room temperature
Melting Point :
183° C
Boiling Point :
581.64° C at 760 mmHg (Predicted)
Density :
~1.39 g/cm3 (Predicted)
Refractive Index :
n20D 1.67 (Predicted)
pK Values :
pKa: 4.7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
NK8226000
PubChem CID :
1548885
Merck Index :
14: 8982
MDL Number :
MFCD00599589
EC Number :
253-819-2
Beilstein Registry :
2951842
SMILES :
CC\\1=C(C2=C(/C1=C/C3=CC=C(C=C3)S(=O)C)C=CC(=C2)F)CC(=O)O

Download SDS (MSDS)

Certificate of Analysis

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Sulindac (CAS 38194-50-2)  Product Citations

See how others have used Sulindac (CAS 38194-50-2). Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 28621918  Anal. Chem. 89: 7398-7405.

PMID: # 32446175  Redox Biol. 34: 101571.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Haanen (PubMed ID 11569947) found that Sulindac Haanen (PubMed ID 11569947) found that Sulindac showed anticancer properties by inhibiting cyclic-GMP phosphodiesterase, increasing cGMP to activate protein kinase G and inducing transcription of caspase genes, resulting in apoptosis. -SCBT Publication Review
Date published: 2015-03-01
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