Suberoylanilide-d5 Hydroxamic AcidA potent, selective, and cell permeable HDAC inhibitor

Suberoylanilide-d5 Hydroxamic Acid (CAS 149647-78-9 (unlabeled))

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Synonym: SAHA-d5; N-Hydroxy-N'-phenyl-d5-octanediamide
Application: A potent, selective, and cell permeable HDAC inhibitor
CAS Number: 149647-78-9 (unlabeled)
Molecular Weight: 269.35
Molecular Formula: C14H15D5N2O3
* Refer to Certificate of Analysis for lot specific data (including water content).
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Suberoylanilide-d5 Hydroxamic Acid is a potent, selective, cell permeable HDAC inhibitor (histone deacetylase). Suberoylanilide-d5 Hydroxamic Acid displays anti-angiogenic activity by interfering with VEGF signaling in human umbilical vein endothelial cells (HUVECs). Suberoylanilide-d5 Hydroxamic Acid induces differentiation in human breast cancer cells.


References

Richon, V.M., et al.: Proc. Natl. Acad.Sci. USA, 95, 3003 (1988) Munster, P.N., et al.: Cancer Res., 61, 8492 (2001) Deroanne, C.F., et al.: Oncogene, 21, 247 (2002)

Physical State :
Solid
Solubility :
Soluble in Dimethyl Sulfoxide and Methanol
Storage :
Store at -20° C
Melting Point :
161-162 °C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
25235331
SMILES :
[2H]C1=C(C(=C(C(=C1[2H])[2H])NC(=O)CCCCCCC(=O)NO)[2H])[2H]

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Certificate of Analysis

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