SU11652A cell-permeable pyrrole-indolinone that acts as a tyrosine kinase receptor & angiogenic inhibitor

SU11652 (CAS 326914-10-7)

SU11652 | CAS 326914-10-7 is rated 5.0 out of 5 by 1.
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Synonym: 5-[(Z)-(5-chloro-1, 2-dihydro-2-oxo-3H-indol-3- ylidene)methyl]-N-[2-(diethylamino)ethyl]-2, 4-dimethyl-1H-pyrrole-3-carboxamide
Application: A cell-permeable pyrrole-indolinone that acts as a tyrosine kinase receptor & angiogenic inhibitor
CAS Number: 326914-10-7
Purity: >97%
Molecular Weight: 414.9
Molecular Formula: C22H27ClN4O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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SU11652 is a potent cell-permeable pyrrole-indolinone compound that acts as an ATP-competitive tyrosine kinase receptor and angiogenic inhibitor that exhibits greater selectivity for PDGFR-β (PDGFRβ, IC50 = 3 nM), Flk-1 (VEGFR2, IC50 = 27 nM), FGFR1 (IC50= 170 nM), and Kit family members (IC50=~10-500 nM) over EGFR (IC50 >20 μM). SU11652 displays anti-proliferative and pro-apoptotic properties in tumor cells.


References

Heryanto, B., et al. 2003. Reproduction 125, 334. Sun, L., et al. 2003. J. Med. Chem. 46, 1116. Liao, A.T., et al. 2002. Blood 100, 585.

Usage :
Following reconstitution, aliquot and freeze at -20°C. Stable for up to 6 months at -20°C.
Physical State :
Solid
Solubility :
Soluble in DMSO (>25 mg/ml).
Storage :
Store at 4° C
Boiling Point :
596.49° C at 760 mmHg (Predicted)
Density :
1.25 g/cm3 (Predicted)
Refractive Index :
n20D 1.63 (Predicted)
IC50 :
PDGFRβ: IC50 = 3 nM; VEGFR2: IC50 = 27 nM; FGFR1: IC50 = 170 nM; Kit family members: IC50 = ~ 10-500 nM; EGFR : IC50 = >20 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
5329103
MDL Number :
MFCD09037560
SMILES :
CCN(CC)CCNC(=O)C1=C(NC(=C1C)/C=C\\2/C3=C(C=CC(=C3)Cl)NC2=O)C

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Guo Guo, Y. et al. (PubMed 23216927) reported that SU11652 inhibits tyrosine kinase activity of FLT3 and growth of MV-4-11 cells. -SCBT Publication Review
Date published: 2015-05-30
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