SU 9516 is a cell permeable, potent, selective and ATP-competitive inhibitor of Cdk2/cyclin A (IC50=22nM), Cdk1/cyclin B (IC50=40nM) and Cdk4/cyclin D1 (IC50=200nM). SU9516 has no effect on the activity of PKC, p38, PDGFRβ and EGFR (IC50>10μM). The compound displays anti-proliferative and pro-apoptotic properties in tumor cells and inhibits proliferation of growth factor-stimulated colon carcinoma cells. SU 9516 does this by binding to Cdk2 and thus preventing the phosphorylation of pRb and its dissociation from E2F.
M.E. Lane, et al.; Cancer Res. 61, 6170 (2001). B. Yu, et al.; Biochem Pharmacol. 64, 1091 (2002). D.J. Moshinsky, et al.; BBRC 310, 1026 (2003). X. Li, et al.; Bioorg. Med. Chem. Lett. 13, 1939 (2003).
See how others have used SU 9516. Click on the entry to view the PubMed entry .
PMID: # 25394488 Su, M. et al. 2015. Cell Death Differ. 22: 986-99.
PMID: # 24101496 Bogdanow, et al. 2013. Proc Natl Acad Sci U S A. 110: 17510-5.
PMID: # 20844576 Zydek, M. et al. 2010. PLoS Pathog. 6: -.
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