SU 6668 is an ATP-competitive PDGFR, Flk-1/KDR and FGFR inhibitor (IC50 values are 0.06, 2.43, 3.04 and > 100μM at PDGFRβ, Flk-1/KDR, Flg/FGFR1 and EGFR respectively). SU 6668 inhibits proliferation of HUVEC and NIH3T3 cells in vitro (IC50 values are 0.41, 9.3 and 16.5 μM for Flk-1/KDR, FGF and PDGF-stimulated growth respectively) and induces > 75% growth inhibition against a broad range of tumor types. SU 6668 shows antiangiogenic, anti-inflammatory, antimetastatic and proapototic activity.
1. Sun, L., et al. 1999. J. Med. Chem. 42: 5120-5130. PMID: 10602697
Soluble in 1eq.NaOH (100 mM), DMSO (62 mg/ml at 25° C), DMF (~5 mg/ml), water (<1 mg/ml at 25° C), and ethanol (<1.2 mg/ml).
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ItohItoh, Y. et al. (PubMed 21737066) used SU 6668, a known PDGFR inhibitor, to successfully suppress the migration of astrocytes and pericytes plated onto a gel matrix containing developed capillary like structures.
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