SU 6668

SU 6668 (CAS 252916-29-3)

SU 6668 | CAS 252916-29-3 is rated 5.0 out of 5 by 1.
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Synonym: 3-[2,4-dimethyl-5-[(E)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid; Orantinib; 3-[2, 4-dimethyl-5-[(E)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl] propanoic acid
Application: An antiproliferating agent and ATP-competitive PDGFR, Flk-1/KDR (VEGF), and FGFR inhibitor
CAS Number: 252916-29-3
Purity: >98%
Molecular Weight: 310.35
Molecular Formula: C18H18N2O3
* Refer to Certificate of Analysis for lot specific data (including water content).
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SU 6668 is an ATP-competitive PDGFR, Flk-1/KDR and FGFR inhibitor (IC50 values are 0.06, 2.43, 3.04 and > 100μM at PDGFRβ, Flk-1/KDR, Flg/FGFR1 and EGFR respectively). SU 6668 inhibits proliferation of HUVEC and NIH3T3 cells in vitro (IC50 values are 0.41, 9.3 and 16.5 μM for Flk-1/KDR, FGF and PDGF-stimulated growth respectively) and induces > 75% growth inhibition against a broad range of tumor types. SU 6668 shows antiangiogenic, anti-inflammatory, antimetastatic and proapototic activity.


References

1. Sun, L., et al. 1999. J. Med. Chem. 42: 5120-5130. PMID: 10602697

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in 1eq.NaOH (100 mM), DMSO (62 mg/ml at 25° C), DMF (~5 mg/ml), water (<1 mg/ml at 25° C), and ethanol (<1.2 mg/ml).
Storage :
Store at room temperature
Melting Point :
239.35° C (Predicted)
Boiling Point :
590.48° C at 760 mmHg (Predicted)
Density :
1.33 g/cm3 (Predicted)
Refractive Index :
n20D 1.68 (Predicted)
IC50 :
Flt-1: IC50 = 28 nM (human); ARK-2: IC50 = 35 nM (human); PDGFR-β: IC50 = 50 nM (human); Flk-1: IC50 = 135 nM; ARK-3: IC50 = 210 nM
pK Values :
pKa: 4.63 (Predicted), pKb: 2.37 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
UX9641810
PubChem CID :
5995546
MDL Number :
MFCD09743433
SMILES :
CC1=C(NC(=C1CCC(=O)O)C)C=C2C3=CC=CC=C3NC2=O

Download SDS (MSDS)

Certificate of Analysis

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SU 6668  Product Citations

See how others have used SU 6668. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 21737066  Itoh, Y. et al. 2011. Brain Res. 1406: 74-83.

PMID: # 10945623  Laird, AD. et al. 2000. Cancer Res. 60: 4152-4160.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Itoh Itoh, Y. et al. (PubMed 21737066) used SU 6668, a known PDGFR inhibitor, to successfully suppress the migration of astrocytes and pericytes plated onto a gel matrix containing developed capillary like structures.
Date published: 2015-03-26
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