SU 4984An Flg tyrosine kinase inhibitor

SU 4984 (CAS 186610-89-9)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 83ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Application: An Flg tyrosine kinase inhibitor
CAS Number: 186610-89-9
Purity: ≥98%
Molecular Weight: 333.38
Molecular Formula: C20H19N3O2
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

SU 4984 is an inhibitor of tyrosine kinase activity of fibroblast growth factor receptor 1 (Flg). SU 4984 also inhibits αFGF-induced tyrosine phosphorylation of ERK1 and ERK2 and the tyrosine phosphorylation of the PDGF receptor and the insulin receptors. it does not, however, inhibit the kinase activity of the EGF receptor.


References

1. Mohammadi, M., et al., 1997. Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors. Science (New York, N.Y.). 276(5314): 955-60. PMID: 9139660

Appearance :
Crystalline
Physical State :
Solid
Solubility :
Soluble in DMSO (25 mg/ml), and acetone.
Storage :
Store at -20° C
Melting Point :
237.06° C (Predicted)
Boiling Point :
649.12° C at 760 mmHg (Predicted)
Density :
1.34 g/cm3 (Predicted)
Refractive Index :
n20D 1.72 (Predicted)
IC50 :
FGFR1: IC50 = 10-20 µM; inhibits aFGF-induced tyrosine phosphorylation of ERK1 and ERK2: IC50 = 20-40 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
5353975
MDL Number :
MFCD08443934
SMILES :
C1CN(CCN1C=O)C2=CC=C(C=C2)/C=C/3\\C4=CC=CC=C4NC3=O

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 105ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 36ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.