Strobilurin B (CAS 65105-52-4)

Strobilurin B is a naturally occurring fungicidal compound, part of the strobilurin class of pesticides, which were first identified as extracts from wood-decaying fungi of the strobilurin group. This compound specifically inhibits mitochondrial respiration in fungi by binding to the ubiquinol oxidation site of complex III in the mitochondrial electron transport chain. This action blocks electron transfer, which is crucial for cellular energy production, leading to a cessation of ATP synthesis and ultimately resulting in fungal cell death. In research, strobilurin B has been extensively used to study the bioenergetic processes of fungal cells, providing insights into mitochondrial dynamics and the mechanisms of energy production in eukaryotic organisms. Its role as a mitochondrial inhibitor also makes it a useful tool in examining the physiological effects of respiratory inhibition in cells, including the study of reactive oxygen species (ROS) production and the induction of programmed cell death pathways. Furthermore, research involving strobilurin B has contributed to understanding how fungi develop resistance to fungicides, helping to explain genetic adaptations that confer resistance, which is crucial for the development of new strategies to manage and circumvent resistance in pathogenic fungi. Through these applications, strobilurin B not only enhances knowledge in fungal physiology but also aids in the advancement of agricultural sciences by informing more effective fungicide use strategies.