Streptozotocin (U-9889) CAS: 18883-66-4
MF: C8H15N3O7
MW: 265.2

Streptozotocin (U-9889) (CAS 18883-66-4)

Streptozotocin (U-9889) | CAS 18883-66-4 is rated 5.0 out of 5 by 4.
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Alternate Names: Streptozotocin (U-9889) is also known as STZ and Zanosar
Application: Streptozotocin (U-9889) is an N-nitroso containing antibiotic and can be used as a potent DNA methylating agent.
CAS Number: 18883-66-4
Purity: ≥98%
Molecular Weight: 265.2
Molecular Formula: C8H15N3O7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Streptozotocin (U-9889) is a small molecule, N-nitroso-containing antibiotic and a potent DNA methylating agent. Streptozotocin (U-9889) acts as a nitric oxide (NO) donor and vasorelaxant. In rat cell studies, Streptozotocin presented significant methylation of the liver, kidney, and pancreatic cells and selectivity for these cells against the more general methylating activity of the aglycone analog N-methyl-N-nitrosourea (sc-212238). Streptozotocin shows particular activity in the pancreas, and has been used both to induce diabetes in mammals and to treat human pancreatic cancers. Streptozotocin (U-9889) is an inhibitor of NCOAT.


References

1. Bennett, R A., et al., 1981. Alkylation of DNA in rat tissues following administration of streptozotocin. Cancer research. 41(7): 2786-90. PMID: 6454479

2. Brentjens, R., et al., 2001. Islet cell tumors of the pancreas: the medical oncologist′s perspective. The Surgical clinics of North America. 81(3): 527-42. PMID: 11459269

3. Johnathan K Smid et. al Endocrinology, 156(3), undefined (2014-12-9). PMID: 25485969

4. Szkudelski, T. The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas Physiol.Res. 50, 536-546 (2001).

5. Kramer, J., Moeller, E.L., Hachey, A., et al. Differential expression of GLUT2 in pancreatic islets and kidneys of New and Old World nonhuman primates American Journal of Physiology.Regulatory, Integrative and Comparative Physiology 296, R786-R793 (2009).

Usage :
Once in solution, release of NO gas occurs spontaneously at room temperature. The rate of release is slowed at -80°C, however, it is recommended the solutions be made immediately before use.
Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Soluble in water (≥53 mg/ml), ethanol ( ≥3 mg/ml), and DMSO (≥53 mg/ml).
Storage :
Store at -20° C
Melting Point :
121° C (dec.)
Boiling Point :
475.23° C (Adapted Stein & Brown method)
Density :
~1.9 g/cm3 (Predicted)
Refractive Index :
n20D 1.67
Optical Activity :
α20/D +39°, c = 1 in water
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
LZ5775000
PubChem CID :
23615975
Merck Index :
14: 8832
MDL Number :
MFCD00006607
EC Number :
242-646-8
Beilstein Registry :
2060675
SMILES :

Download SDS (MSDS)

Certificate of Analysis

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Streptozotocin (U-9889) (CAS 18883-66-4)  Product Citations

See how others have used Streptozotocin (U-9889) (CAS 18883-66-4). Click on the entry to view the PubMed entry .

Citations 1 to 10 of 46 total

PMID: # 31168342  Ashrafi Jigheh, Z.|Ghorbani Haghjo, A.|Argani, H.|Roshangar, L.|Rashtchizadeh, N.|Sanajou, D.|Nazari Soltan Ahmad, S.|Rashedi, J.|Dastmalchi, S.|Mesgari Abbasi, M.| et al. 2019. Iran J Basic Med Sci. 22: 384-390.

PMID: # 30981189  Sekar, V.|Mani, S.|Malarvizhi, R.|Nithya, P.|Vasanthi, HR.| et al. 2019. Phytomedicine. 59: 152901.

PMID: # 29948786  Sanajou, D. et al. 2018. J. Physiol. Biochem.

PMID: # 28801114  Bassani, TB. et al. 2017. Behav. Brain Res. 335: 41-54.

PMID: # 28622041  Yildirimturk, S. et al. 2017. J Cosmet Laser Ther. 19: 397-403.

PMID: # 28284945  Siba, IP. et al. 2017. Behav. Brain Res. 326: 173-186.

PMID: # 28623617  Bassani, TB. et al. 2017. Mol. Neurobiol.

PMID: # 28799955  Gambeta, E. et al. 2017. Behav Pharmacol. 28: 558-564.

PMID: # 27521417  Koncsos, G. et al. 2016. Am. J. Physiol. Heart Circ. Physiol. 311: H927-H943.

PMID: # 27206737  Demirci, S.|Doğan, A.|Aydın, S.|Dülger, EÇ.|Şahin, F.| et al. 2016. Mol. Cell. Biochem. 417: 119-33.

Citations 1 to 10 of 46 total

Hello; we will use it our experimental animals (rat), for make diabets, How many milligrams should we give per animals..?

Asked by: Rota35
Unfortunately we are not able to provide that information. Our compounds are not pharmaceutical grade and not manufactured under GMP guidelines. Please consult your principal investigator and your animal care and use committee (ACUC) regarding the use of our compounds.
Answered by: Technical Support
Date published: 2020-05-27

What is the appearance of the compound?

Asked by: two2igm05
The compound is pale yellow crystalline powder.
Answered by: Chemical Support 4
Date published: 2017-02-25

Eu sou da UEPG, Universidade Estadual de Ponta Grossa-Pr, solicito orçamento do produto: STREPTOZOTOCIN 1g, para compra direta, juntamente com os dados de sua empresa, obrigado. Nosso cnpj é 80.257.355/0001-08, meu nome é José Claudinei de Arruda.

Asked by: Arruda
Thank you for your question. Please contact one of our authorized distributors in Brazil to receive a quote for this chemical, sc-200719: Streptozotocin (U-9889). A complete list of our distributors can be found using the link below, or by selecting Distributors, under Resources in the menu at the bottom of our website. https://www3.scbt.com/scbt/resources/distributors
Answered by: Technical Support
Date published: 2016-09-19
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Rated 5 out of 5 by from Great feature I bought this product a month ago. Delivery was very fast and the price is great. Excellent product.
Date published: 2018-04-25
Rated 5 out of 5 by from Thanks SCBT I bought 2gm STZ from SCBT one month ago and I got it so fast. STZ was very effective and very good price.
Date published: 2017-01-19
Rated 5 out of 5 by from Great features! I bought this a month ago and have used it to successfully induce the diabetic model in mice!
Date published: 2016-12-19
Rated 5 out of 5 by from Santos Santos, et al (PubMed ID 19096034) found that streptozotocin increases BACE levels, AChE activity and oxidative stress in the mouse hippocampus. Also confirmed that cognitive impairment was achieved by the use of STZ. -SCBT Publication Review
Date published: 2015-06-24
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