Streptonigrin is an aminoquinone antitumour antibiotic and phenylpyridylquinoline. The antineoplastic activity of Streptonigrin requires reductive activation by Xanthine-converting enzymes. Streptonigrin induces apoptosis by a mechanism involving NF-kB. Streptonigrin (10 μg/ml) inhibits DNA synthesis in and reduces survival of S. typhimurium bacteria. Streptonigrin is also known as Bruneomycin, Nigrin, SN, and (4R)-5-amino-6-(7-amino-5,8-dihydro-6-methoxy-5,8-dioxo-2-quinolinyl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methyl-2-pyridinecarboxylic acid.
Soluble in DMF, DMSO, ethanol (moderately), methanol (moderately), and water (poorly).
Store at -20° C
~736.2° C at 760 mmHg (Predicted)
~1.6 g/cm3 (Predicted)
n20D 1.72 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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