STO-609 acetate saltA selective CaMKK inhibitor

STO-609 acetate salt (CAS 1173022-21-3)

STO-609 acetate salt | CAS 1173022-21-3 is rated 5.0 out of 5 by 2.
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Synonym: 7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid, acetate salt
Application: A selective CaMKK inhibitor
CAS Number: 1173022-21-3
Purity: ≥98%
Molecular Weight: 374.35
Molecular Formula: C19H10N2O3•C2H4O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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STO-609 is a naphthoyl fused benzimidazole cell-permeable compound. It is known to be a very potent and selective ATP-competitive CaMKK inhibitor. STO-609 has been shown to bind to the CaMKK catalytic domain, thus inhibiting autophosphorylation. STO-609 has not been found to significantly affect the activities of MLCK, CaMKII, CaMKI, CaMKIV, PKC, PKA, or p42 MAP kinase. It has been observed to inhibit AMP-activated protein kinase phosphorylation. STO-609 is an inhibitor of CaMKK α and CaMKK β and an activator of aryl hydrocarbon receptor.


References

1. Tokumitsu, H., et al. 2002. J. Biol. Chem. 277: 15813-15818. PMID: 11867640
2. Tokumitsu, H., et al. 2003. J. Biol. Chem. 278: 10908-10913. PMID: 12540834
3. Levine, Y.C., et al. 2007. J. Biol. Chem. 282: 20351-20364. PMID: 17519230

Physical State :
Solid
Solubility :
Soluble in DMSO (10 mg/ml), and 100 mM NaOH (20 mg/ml).
Storage :
Store at -20° C
Melting Point :
300° C
Refractive Index :
n20D 1.80 (Predicted)
IC50 :
CaMKKβ: IC50 = 40 ng/ml; CamKKα: IC50 = 120 ng/ml; MLCK: IC50 = ~10 µg/ml; p42 MAP kinase: IC50 = >10 µg/ml; CaMKIV: IC50 = >10 µg/ml (human)
Ki Data :
CaMKKβ: Ki= 15 ng/ml; CamKKα: Ki= 80 ng/ml
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
16760660
MDL Number :
MFCD06411456
SMILES :
CC(=O)O.C1=CC=C2C(=C1)N=C3N2C(=O)C4=CC=CC5=C(C=CC3=C54)C(=O)O

Download SDS (MSDS)

Certificate of Analysis

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STO-609 acetate salt  Product Citations

See how others have used STO-609 acetate salt. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 11 total

PMID: # 30545741  Aghanoori, MR.|Smith, DR.|Shariati-Ievari, S.|Ajisebutu, A.|Nguyen, A.|Desmond, F.|Jesus, CHA.|Zhou, X.|Calcutt, NA.|Aliani, M.|Fernyhough, P.| et al. 2019. Mol Metab. 20: 149-165.

PMID: # 31038133  Zhao, Y.|Zhou, Y.|Wang, M.| et al. 2019. Food Funct.

PMID: # 30893014  Kast, DJ.|Dominguez, R.| et al. 2019. Mol. Biol. Cell. 30: 1285-1297.

PMID: # 31155724  Xi, G. et al. 2019. J. Cell. Physiol.

PMID: # 29914450  MacDonald, AF.|Bettaieb, A.|Donohoe, DR.|Alani, DS.|Han, A.|Zhao, Y.|Whelan, J.| et al. 2018. BMC Complement Altern Med. 18: 188.

PMID: # 29277967  Cheng, C. et al. 2018. Cancer Med. 7: 380-396.

PMID: # 27864646  Yan, X. et al. 2017. Lasers Med Sci. 32: 169-180.

PMID: # 27869123  Dalle Pezze, P.|Ruf, S.|Sonntag, AG.|Langelaar-Makkinje, M.|Hall, P.|Heberle, AM.|Razquin Navas, P.|van Eunen, K.|Tölle, RC.|Schwarz, JJ.|Wiese, H.|Warscheid, B.|Deitersen, J.|Stork, B.|Fäßler, E.|Schäuble, S.|Hahn, U.|Horvatovich, P.|Shanley, DP.|Thedieck, K.| et al. 2016. Nat Commun. 7: 13254.

PMID: # 25080865  Groenendijk, FH. et al. 2015. Int. J. Cancer. 136: 1434-44.

PMID: # 23103546  Morotomi-Yano, K. et al. 2012. Biochem. Biophys. Res. Commun. 428: 371-5.

Citations 1 to 10 of 11 total
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Date published: 2015-05-13
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Date published: 2015-03-31
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