Sterigmatocystin CAS: 10048-13-2
MF: C18H12O6
MW: 324.28
A DNA synthesis inhibitor.

Sterigmatocystin (CAS 10048-13-2)

Sterigmatocystin | CAS 10048-13-2 is rated 4.0 out of 5 by 1.
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Alternate Names: 3a,12c-Dihydro-8-hydroxy-6-methoxy-7H-furol[3',2':4,5]furo[2,3-c]xanthen-7-one
Application: Sterigmatocystin is a DNA synthesis inhibitor
CAS Number: 10048-13-2
Molecular Weight: 324.28
Molecular Formula: C18H12O6
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Sterigmatocystin is a mycotoxin produced by common mold strains. It induces sister chromatid exchanges in bone marrow cells of mice and has been shown to induce lung and liver tumors in vitro, as well as necrosis of the liver. Sterigmatocystin may function to inhibit of p21, and thereby DNA synthesis.


References

1. Terao, K., et al., 1973. Massive and single cell necrosis in the rat liver induced by aflatoxin B1 and sterigmatocystin. Acta pathologica japonica. 23(3): 647-53. PMID: 4800731
2. Nel, W., et al., 1970. Effect of sterigmatocystin on rat liver nuclear RNA. Biochemical pharmacology. 19(3): 957-9. PMID: 5507701
3. Curry, P T., et al., . Induction of sister-chromatid exchanges in vivo in mice by the mycotoxins sterigmatocystin and griseofulvin. Mutation research. 137(2-3): 111-5. PMID: 6472322
4. Bünger, Jürgen., et al., 2004. Cytotoxicity of occupationally and environmentally relevant mycotoxins. Toxicology. 202(3): 199-211. PMID: 15337583
5. Kamei, K., et al., 2005. Aspergillus mycotoxins and their effect on the host. Medical mycology. 43 Suppl 1(): S95-9. PMID: 16110799
6. Yao, Dong-Sheng., et al., 2006. A novel biosensor for sterigmatocystin constructed by multi-walled carbon nanotubes (MWNT) modified with aflatoxin-detoxifizyme (ADTZ). Bioelectrochemistry (Amsterdam, Netherlands). 68(2): 126-33. PMID: 16122991
7. Ehrlich, Kenneth C., et al., 2005. An aflatoxin biosynthesis cluster gene encodes a novel oxidase required for conversion of versicolorin a to sterigmatocystin. Applied and environmental microbiology. 71(12): 8963-5. PMID: 16332900

Physical State :
Solid
Derived From :
Aspergillus versicolor
Solubility :
Soluble in DMSO (10 mg/ml), chloroform (71 mg/ml), ethanol, methanol, and water.
Storage :
Store at -20° C
Melting Point :
236-239° C
Boiling Point :
569.75° C at 760 mmHg (Predicted)
Density :
1.51 g/cm3 (Predicted)
Refractive Index :
n20D 1.69 (Predicted)
Optical Activity :
α20/D -398°, c = 1 in chloroform
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
LV1750000
Transport :
UN 3462, Class 6.1, Packing group III
PubChem CID :
MDL Number :
MFCD00005084
EC Number :
233-158-6
Beilstein Registry :
53259
SMILES :
COC1=C2C(=C3[[email protected]@H]4C=CO[[email protected]@H]4OC3=C1)OC5=C(C2=O)C(=CC=C5)O

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Certificate of Analysis

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Sterigmatocystin (CAS 10048-13-2)  Product Citations

See how others have used Sterigmatocystin (CAS 10048-13-2). Click on the entry to view the PubMed entry .

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PMID: # 31758414  J Ind Microbiol Biotechnol. 155-168.

Citations 1 to 1 of 1 total
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Date published: 2015-04-20
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