Stem-Cell Factor/c-Kit Inhibitor, ISCK03A c-kit activity inhibitor

Stem-Cell Factor/c-Kit Inhibitor, ISCK03 (CAS 945526-43-2)

Stem-Cell Factor/c-Kit Inhibitor, ISCK03 | CAS 945526-43-2 is rated 5.0 out of 5 by 1.
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Synonym: 4-t-Butylphenyl-N-(4-imidazol-1-yl-phenyl)sulfonamide; SCF/c-Kit Signaling Inhibitor
Application: A c-kit activity inhibitor
CAS Number: 945526-43-2
Purity: ≥97%
Molecular Weight: 355.5
Molecular Formula: C19H21N3O2S
* Refer to Certificate of Analysis for lot specific data (including water content).
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Stem-Cell Factor/c-Kit Inhibitor, ISCK03 is a cell-permeable phenyl-imidazolosulfonamide compound that inhibits c-kit activity (IC50 <<2.5 μM in cell-free kinase assays) and blocks SCF-induced c-kit and Erk phosphorylation (1 μM causes >90% inhibition) without any effect on HGF-induced Erk phosphorylation in 501mel melanoma cells.


References

1. Na, Y.J., et al. 2007. Biochem. Pharmacol. 74: 780-786. PMID: 17658483

Physical State :
Solid
Solubility :
Soluble in DMSO (10 mg/ml), and ethanol (5 mg/ml). Insoluble in water.
Storage :
Store at 4° C
Melting Point :
230.08° C (Predicted)
Boiling Point :
519.99° C at 760 mmHg (Predicted)
Density :
1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.61 (Predicted)
IC50 :
c-kit activity: IC50 = <<2.5 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
1
PubChem CID :
3792751
MDL Number :
MFCD12031591
SMILES :
CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)NC2=CC=C(C=C2)N3C=CN=C3

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Certificate of Analysis

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Stem-Cell Factor/c-Kit Inhibitor, ISCK03  Product Citations

See how others have used Stem-Cell Factor/c-Kit Inhibitor, ISCK03. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 25887124  Tan, KS. et al. 2015. Biology open. 4: 596-607.

PMID: # 23562441  Wygrecka, M. et al. 2013. The American journal of pathology. 182: 2094-108.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Na Na, et al. (PubMed ID 17658483) pre-treated 501mel cells with various dosages of ISCK03, a cell permeable c-Kit inhibitor, to study their effects on inhibition when stimulated by SCF. -SCBT Publication Review
Date published: 2015-04-17
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