Stem-Cell Factor/c-Kit Inhibitor, ISCK03 is a cell-permeable phenyl-imidazolosulfonamide compound that inhibits c-kit activity (IC50 <<2.5 μM in cell-free kinase assays) and blocks SCF-induced c-kit and Erk phosphorylation (1 μM causes >90% inhibition) without any effect on HGF-induced Erk phosphorylation in 501mel melanoma cells.
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NaNa, et al. (PubMed ID 17658483) pre-treated 501mel cells with various dosages of ISCK03, a cell permeable c-Kit inhibitor, to study their effects on inhibition when stimulated by SCF. -SCBT Publication Review
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