Stearic AcidAn anti-inflammatory agent that induces ICAM-1 expression

Stearic Acid (CAS 57-11-4)

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Synonym: Octadecanoic Acid; 1-Heptadecanecarboxylic acid; C18:0; Cetylacetic acid; Stearophanic acid
Application: An anti-inflammatory agent that induces ICAM-1 expression
CAS Number: 57-11-4
Molecular Weight: 284.5
Molecular Formula: C18H36O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Stearic Acid, an anti-inflammatory agent, is the hydrogenation product of linoleic acid. This compound has been shown to induce a decrease of cell growth and adhesion and increase hydrophobic properties of collagen films. This was achieved via reaction of lysyl amino groups of the α-chain of collagen films with stearate, which causes a decrease in chemical groups exposed on the surface of the films. Stearic Acid has been noted to induce an increase in ICAM-1 expression in cells, via an increase in phosphorylation of the transcriptional regulator NFκB.


References

1. Zock, P.L., et al. 1992. J. Lipid Res. 33: 399-410. PMID: 1569387
2. Forest, P.O., et al. 2007. J Biomed Mater Res A. 80: 758-767. PMID: 17133448
3. Sundram, K., et al. 2007. Nutr Metab. 4: 3. PMID: 17224066
4. Tsubura, A., et al. 2009. Histol. Histopathol. 24: 223-234. PMID: 19085838

Physical State :
Solid
Solubility :
Soluble in ethanol (~20 mg/ml), DMSO (~10 mg/ml), DMF (~30 mg/ml), CCl4 (1 g/6m), chloroform, acetone, and carbondisulfide. Insoluble in water.
Storage :
Store at room temperature
Melting Point :
67-70° C (lit.)
Boiling Point :
232° C at 15 mmHg
Density :
0.85 g/cm3
Refractive Index :
n20D 1.46 (Predicted)
IC50 :
Cyclooxygenase-2: IC50 = >500 µM (Ovis aries); Cyclooxygenase-1: IC50 = >500 µM (Bos taurus); HT-29: IC50 = >200 µM (human)
pK Values :
pKa: 4.78
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
1
RTECS :
WI2800000
PubChem CID :
5281
Merck Index :
14: 8804
MDL Number :
MFCD00002752
EC Number :
200-313-4
Beilstein Registry :
608585
SMILES :
CCCCCCCCCCCCCCCCCC(=O)O

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Stearic Acid  Product Citations

See how others have used Stearic Acid. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 26549524  Thorsteinsdottir, UA. et al. 2016. Phytother Res. 30: 97-104.

Citations 1 to 1 of 1 total
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