STEARDACAS: 105955-10-0
MF: C26H45NO3
MW: 419.64
A 5-LO (5-lipoxygenase) inhibitor.

STEARDA (CAS 105955-10-0)

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Synonym: N-(3,4-dihydroxyphenethyl)stearamide
Application: A 5-LO (5-lipoxygenase) inhibitor
CAS Number: 105955-10-0
Purity: ≥92%
Molecular Weight: 419.64
Molecular Formula: C26H45NO3
* Refer to Certificate of Analysis for lot specific data (including water content).
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STEARDA inhibits arachidonate 5-LO (5-lipoxygenase) with an IC50 of 16 nM. Adiditionally, is an ndogenous fatty acid dopamide that displays 'entourage' effects on endovanilloids NADA and anandamide. STEARDA is inactive at TRPV1 and CB1 receptors (at concentrations up to 5 μM) and does not inhibit AMT or FAAH (IC50 > 25 μM). However, STEARDA potentiates TRPV1-mediated effects of NADA in vitro and in vivo; enhances effects on intracellular Ca2+ (EC50 lowered 3-fold) and nociception. Also, STEARDA inhibits arachidonate 5-lipoxygenase (IC50 = 16 nM).


References

Chu et al (2003) N-Oleoyldopamine, a novel endogenous capsaicin-like lipid that produces hyperalgesia. J.Biol.Chem. 278 13633. De Petrocellis et al (2004) Actions of two naturally occurring saturated N-acyldopamines on transient receptor potential vanilloid 1 (TRPV1) channels. Br.J.Pharmacol. 143 251.

Physical State :
Solid
Solubility :
Soluble to 5 mM in Ethanol
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
10025103
SMILES :
CCCCCCCCCCCCCCCCCC(=O)NCCC1=CC(=C(C=C1)O)O

Download SDS (MSDS)

Certificate of Analysis

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