Stat5 Inhibitor InhibitorA cell-permeable Stat5, SH2 domain target

Stat5 Inhibitor Inhibitor (CAS 285986-31-4)

Stat5 Inhibitor | CAS 285986-31-4 is rated 5.0 out of 5 by 1.
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Synonym: N′-((4-Oxo-4H-chromen-3-yl)methylene)nicotinohydrazide
Application: A cell-permeable Stat5, SH2 domain target
CAS Number: 285986-31-4
Purity: ≥97%
Molecular Weight: 293.28
Molecular Formula: C16H11N3O3
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Stat5 Inhibitor is a cell permeable nonpetidic nicotinoyl hydrazone which suppresses Stat5 via binding to the SH2 domain. Studies indicate that Stat5 Inhibitor suppresses the SH2 domain of Stat1 and Stat3 to a lesser extent than Stat5 inhibition. In addition, Stat5/Stat5 DNA binding in K562 nuclear extracts are inhibited by Stat5 Inhibitor. Stat5 functions biologically in various processes such as homeostasis of hematopoietic stem cells, development of blood cells, growth hormone effects, and differentiation of mammary epithelium.


References

1. Bydder, G.M. 1988. Br J Radiol. 61(730): 889-897. PMID: 3056559

2. Müller, J., et al. 2008. Chembiochem. 9: 723-727. PMID: 18247434

3. Jones, N., et al. 2019. Nat. Commun. 10(1): 2042. PMID: 31053703

Usage :
It is recommended to use solutions in the same day the are made. If needed to store a solutions, aliquot into useable amounts and store up to 3 months at -20°C.
Physical State :
Solid
Solubility :
Soluble in DMSO (25 mg/ml).
Storage :
Store at 4° C
Density :
1.33 g/cm3 (Predicted)
Refractive Index :
n20D 1.66 (Predicted)
IC50 :
STAT5b SH2 domain EPO peptide binding activity: IC50 = 47 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
2726045
MDL Number :
MFCD00124694
SMILES :
C1=CC=C2C(=C1)C(=O)C(=CO2)C=NNC(=O)C3=CN=CC=C3

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Certificate of Analysis

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Stat5 Inhibitor Inhibitor  Product Citations

See how others have used Stat5 Inhibitor Inhibitor. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 28 total

PMID: # 31263095  2019. Cell Death Dis. 10: 506.

PMID: # 30429452  Lee, KM.|Park, KH.|Hwang, JS.|Lee, M.|Yoon, DS.|Ryu, HA.|Jung, HS.|Park, KW.|Kim, J.|Park, SW.|Kim, SH.|Chun, YM.|Choi, WJ.|Lee, JW.| et al. 2018. Cell Death Dis. 9: 1136.

PMID: # 28912852  Jin, Z. et al. 2017. Exp Ther Med. 14: 2992-2998.

PMID: # 28500307  Wang, Y.|Skibbe, JR.|Hu, C.|Dong, L.|Ferchen, K.|Su, R.|Li, C.|Huang, H.|Weng, H.|Huang, H.|Qin, X.|Jin, J.|Chen, J.|Jiang, X.| et al. 2017. Sci Rep. 7: 1853.

PMID: # 29104499  Pan, Y.|Yang, XH.|Guo, LL.|Gu, YH.|Qiao, QY.|Jin, HM.| et al. 2017. Int. J. Biol. Sci. 13: 1329-1340.

PMID: # 26774171  DeBoer, J. et al. 2016. Virology. 489: 282-91.

PMID: # 25811804  So, WY. et al. 2015. Cell Death Dis. 6: e1707.

PMID: # 26448755  Ruppert, SM. et al. 2015. Int J Cell Biol. 2015: 614297.

PMID: # 25801035  Xu, W. et al. 2015. Cell Rep. 10: 2043-54.

PMID: # 25330355  Nakonechnaya, AO. et al. 2015. Endocr. Res. 40: 97-105.

Citations 1 to 10 of 28 total

Is Stat5 Inhibitor sterile?

Asked by: ChemSynth123
sc-355979 (Stat5 Inhibitor: CAS 285986-31-4) is not sterile.
Answered by: Chemical Support 7
Date published: 2017-06-12

What is the shelf life?

Asked by: chemsd02
Thank you for your question. sc-355979 (Stat5 Inhibitor, CAS 285986-31-4) has a shelf life of 2+ years when stored at 4°C. It is recommended to use solutions in the same day the are made.
Answered by: Chemical Support 10
Date published: 2017-03-08
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Rated 5 out of 5 by from Liao Liao, Z. et al. (PMC 3056559) found that Stat5 Inhibitor (N'-((4-Oxo-4H-chromen-3-yl)methylene)nicotinohydrazide) was the most potent inhibitor of Stat5 with an IC50 of 47 M. -SCBT Publication Review
Date published: 2015-02-12
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