Stat3 inhibitor V, statticAn inhibitor of Stat3 activation

Stat3 inhibitor V, stattic (CAS 19983-44-9)

Stat3 inhibitor V, stattic | CAS 19983-44-9 is rated 5.0 out of 5 by 2.
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Synonym: 6-Nitrobenzo[b]thiophene-1,1-dioxide; 6-Nitrobenzo[b]thiophene-1,1-dioxide; Stat three inhibitory compound
Application: An inhibitor of Stat3 activation
CAS Number: 19983-44-9
Purity: >95%
Molecular Weight: 211.19
Molecular Formula: C8H5NO4S
* Refer to Certificate of Analysis for lot specific data (including water content).
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Stat3 Inhibitor V, Stattic is a small molecule shown to selectively inhibit the activation of the Stat3 transcription factor by blocking phosphorylation and dimerization events. Stattic has been used as a tool for probing the upstream activation of this factor, significantly expressed in many cancer cell lines, and interruption of this pathway in breast cancer cell lines lead to an increased apoptotic rate in these cells. Stat3 Inhibitor V, Stattic is an inhibitor of Stat3.


References

1. Schust, J., et al. 2006. Chem. Biol. 13: 1235-1242. PMID: 17114005

Physical State :
Solid
Solubility :
Soluble in ethanol (5 mM), and DMSO (50 mM). Insoluble in water.
Storage :
Store at -20° C
Melting Point :
129.80° C (Predicted)
Boiling Point :
~461.1° C (Predicted)
Density :
~1.6 g/cm3 (Predicted)
Refractive Index :
n20D 1.67 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
2779853
MDL Number :
MFCD00173799
SMILES :
C1=CC(=CC2=C1C=CS2(=O)=O)[N+](=O)[O-]

Download SDS (MSDS)

Certificate of Analysis

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Stat3 inhibitor V, stattic  Product Citations

See how others have used Stat3 inhibitor V, stattic. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 50 total

PMID: # 31393941  Li, W.|Cho, MY.|Lee, S.|Jang, M.|Park, J.|Park, R.| et al. 2019. PLoS ONE. 14: e0220860.

PMID: # 31228946  Lu, C. et al. 2019. J Immunother Cancer. 7: 157.

PMID: # 30103900  Sharapova, TN.|Romanova, EA.|Sashchenko, LP.|Yashin, DV.| et al. 2018. Biochimie. 152: 174-180.

PMID: # 30024306  Kim, H. et al. 2018. Am. J. Physiol. Lung Cell Mol. Physiol. 315: L595-L608.

PMID: # 29797567  Kim, E. et al. 2018. J. Cell. Physiol. 233: 8790-8801.

PMID: # 30587839  Fan, Y. et al. 2018. Cancers (Basel). 11:

PMID: # 29913153  Shen, L.|Ke, Q.|Chai, J.|Zhang, C.|Qiu, L.|Peng, F.|Deng, X.|Luo, Z.| et al. 2018. Exp. Cell Res. 370: 127-136.

PMID: # 27750041  Wu, YS. et al. 2017. Biochim. Biophys. Acta. 1861: 296-306.

PMID: # 28499822  Aghazadeh, S.|Yazdanparast, R.| et al. 2017. Biochim Biophys Acta Gen Subj. 1861: 1970-1980.

PMID: # 28405527  Lu, C.|Talukder, A.|Savage, NM.|Singh, N.|Liu, K.| et al. 2017. Oncoimmunology. 6: e1291106.

Citations 1 to 10 of 50 total

Hello, is there and HPLC protocol available for the detection of this compound? Thanks

Asked by: Francesco Mainini
Thank you for your question. We do not provide such a protocol. Please contact our technical service for further information.
Answered by: SCBT Heidelberg Support
Date published: 2019-01-06
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Rated 5 out of 5 by from Works great! I bought this last year and it works really well to inhibit pSTAT3.
Date published: 2018-05-21
Rated 5 out of 5 by from Reitsuma Reitsuma, JM. et al. (PubMed 23903834) used sc-202818 (Stat3 inhibitor V, Stattic), on MRC-5 fibroblasts, ARPE19 epithelial cells, and U373 astrocytoma cells. Found that Stat3 inhibition resulted in diminished human cytomegalovirus genome replication. -SCBT Publication Review
Date published: 2015-02-13
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