STA-21A Stat3 transcription factor signaling inhibitor

STA-21 (CAS 28882-53-3)

STA-21 | CAS 28882-53-3 is rated 5.0 out of 5 by 1.
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Synonym: (S)-Ochromycinone; Deoxytetrangomycin
Application: A Stat3 transcription factor signaling inhibitor
CAS Number: 28882-53-3
Purity: ≥98%
Molecular Weight: 306.31
Molecular Formula: C19H14O4
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

STA-21 is a small molecule that blocks constitutive Stat3 (signal transducer and activator of transcription 3) signaling by impeding Stat3 DNA binding, Stat3 dimerization, and Stat3-dependent luciferase activity. STA-21 displays minimal effect on cells not expressing constitutive Stat3 signaling.


1. Song, H., et al. 2005. Proc. Natl. Acad. Sci. U.S.A. 102: 4700-4705. PMID: 15781862

Physical State :
Solubility :
Soluble in DMSO (20 mg/ml), chloroform, ethyl acetate, and methanol.
Storage :
Store at -20° C
Melting Point :
208.95° C (Predicted)
Boiling Point :
~568.60° C at 760 mmHg (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.67 (Predicted)
IC50 :
DU-145 : IC50 = 12.2 µM (human); PC-3 : IC50 = 18.7 µM (human); MCF7 : IC50 = 124 µM (human)
pK Values :
pKa: 6.61 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :

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Certificate of Analysis

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STA-21  Product Citations

See how others have used STA-21. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 33 total

PMID: # 30784360  Shiraiwa, K.|Matsuse, M.|Nakazawa, Y.|Ogi, T.|Suzuki, K.|Saenko, V.|Xu, S.|Umezawa, K.|Yamashita, S.|Tsukamoto, K.|Mitsutake, N.| et al. 2019. Thyroid. 29: 674-682.

PMID: # 29367208  Smith, CJ.|Allard, DE.|Wang, Y.|Howard, JF.|Montgomery, SA.|Su, MA.| et al. 2018. J. Immunol. 200: 1580-1592.

PMID: # 28980745  Li, X.|Shi, S.|Chen, J.|Zhong, G.|Li, X.|Liu, Z.| et al. 2018. Cell Biol. Int. 42: 169-179.

PMID: # 30050103  Rocha, MR.|Barcellos-de-Souza, P.|Sousa-Squiavinato, ACM.|Fernandes, PV.|de Oliveira, IM.|Boroni, M.|Morgado-Diaz, JA.| et al. 2018. Sci Rep. 8: 11285.

PMID: # 27702388  Bai, T.|Liu, F.|Zou, F.|Zhao, G.|Jiang, Y.|Liu, L.|Shi, J.|Hao, D.|Zhang, Q.|Zheng, T.|Zhang, Y.|Liu, M.|Li, S.|Qi, L.|Liu, JY.| et al. 2017. Stem Cells Dev. 26: 113-122.

PMID: # 28584133  Genini, D.|Brambilla, L.|Laurini, E.|Merulla, J.|Civenni, G.|Pandit, S.|D'Antuono, R.|Perez, L.|Levy, DE.|Pricl, S.|Carbone, GM.|Catapano, CV.| et al. 2017. Proc. Natl. Acad. Sci. U.S.A. 114: E4924-E4933.

PMID: # 27984001  Nadeem, A.|Al-Harbi, NO.|Ansari, MA.|Al-Harbi, MM.|El-Sherbeeny, AM.|Zoheir, KMA.|Attia, SM.|Hafez, MM.|Al-Shabanah, OA.|Ahmad, SF.| et al. 2017. Biochem. Pharmacol. 124: 69-82.

PMID: # 27748869  Wan, J.|Shan, Y.|Fan, Y.|Fan, C.|Chen, S.|Sun, J.|Zhu, L.|Qin, L.|Yu, M.|Lin, Z.| et al. 2016. Mol Med Rep. 14: 4505-4510.

PMID: # 27133258  Choi, G.|Chung, Y.| et al. 2016. Biomol Ther (Seoul). 24: 244-51.

PMID: # 26959508  Wang, L.|Zhao, J.|Ren, JP.|Wu, XY.|Morrison, ZD.|Elgazzar, MA.|Ning, SB.|Moorman, JP.|Yao, ZQ.| et al. 2016. AIDS. 30: 1521-1531.

Citations 1 to 10 of 33 total

Hello, I was looking for a stat-3 inhibitor soluble in ethanol and possibly specific for mouse cells. Could you please give me price and availability of all stat-3 inhibitors which follows these characteristics? Thanks Francesco

Asked by: Francesco Mainini
Thank you very much for your question. Please contact our Technical Service by phone or email or by Live Chat.
Answered by: SCBT Heidelberg Support
Date published: 2018-11-27

I dissolved sc-200757(STA-21) completely in DMSO. When I added my solution to cell culture media a yellow crystal precipitate appeared. Do you have any recommendations?

Asked by: Chemsynth123
Thank you for your question. STA-21 (CAS 28882-53-3): sc-200757 is soluble in DMSO up to 20mg/mL. Using a lower inhibitor concentration my prevent precipitation when adding the DMSO solution to cell culture media.
Answered by: Chemical Support 7
Date published: 2017-03-01
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Rated 5 out of 5 by from Segatto et al Segatto et al. (PubMed ID 25026286) used STA-21, a STAT3 signaling inhibitor, to study the role of STAT transcription factors in post-surgery wound response of breast cancer cells. -SCBT Publication Review
Date published: 2015-03-17
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