SSR 69071 CAS: 344930-95-6
MF: C27H32N4O7S
MW: 556.63
A potent leukocyte elastase inhibitor.

SSR 69071 (CAS 344930-95-6)

SSR 69071 | CAS 344930-95-6 is rated 5.0 out of 5 by 1.
  • y_2021, m_7, d_30, h_19
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.18
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_203702, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 132ms
  • REVIEWS, PRODUCT
loading
5
1
4
0
3
0
2
0
1
0
Alternate Names: 2-[[6-Methoxy-4-(1-methylethyl)-1,1 -dioxido-3-oxo-1,2-benzisothiazol-2(3H)-yl]methoxy]-9-[2-(1-piperidinyl)ethoxy]-4H-pyrido[1,2-a]pyrimidin-4-one
Application: SSR 69071 is a potent leukocyte elastase inhibitor
CAS Number: 344930-95-6
Purity: >98%
Molecular Weight: 556.63
Molecular Formula: C27H32N4O7S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
loading

SSR 69071 is a high affinity, potent inhibitor of Neutrophil Elastase (human leukocyte elastase, HLE) (IC50 = 3.9 nM). SSR 69071 displays species-selectivity (Ki values are 0.017, 1.70, 3.01, 58 and > 100 nM for human, mouse, rat, rabbit and porcine elastase respectively).


References

1. Bidouard, J.P., et al. 2003. Eur. J. Pharmacol. 461: 49-52.
2. Varga, M., et al. 2003. Eur. J. Med. Chem. 38: 421-425
3. Kapui, Z., et al. 2003. J. Pharmacol. Exp.Ther. 305: 451-459.

Physical State :
Solid
Solubility :
Soluble in ethanol (40 mM), and DMSO (25 mM).
Storage :
Store at 4° C
Boiling Point :
763.26° C at 760 mmHg (Predicted)
Density :
1.42 g/cm3 (Predicted)
Refractive Index :
n20D 1.66 (Predicted)
IC50 :
Neutrophil Elastase: IC50 = 3.9 nM (human)
Ki Data :
Elastase: Ki= 17 pM (human)Elastase: Ki= 1.7 nM (mouse); Elastase: Ki= 3.01 nM (rat); Elastase: Ki= 58 nM (rabbit); Elastase: Ki>100 nM (porcine);
pK Values :
pKb: 8.64 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
MDL Number :
MFCD09027353
SMILES :
CC(C)C1=CC(=CC2=C1C(=O)N(S2(=O)=O)COC3=CC(=O)N4C=CC=C(C4=N3)OCCN5CCCCC5)OC

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

SSR 69071 (CAS 344930-95-6)  Product Citations

See how others have used SSR 69071 (CAS 344930-95-6). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 28837503  Pain. 2243-2258.

Citations 1 to 1 of 1 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 118ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Bidoudard et al Bidoudard et al. (PubMed ID 12568915) found that SSR 69071 decreased myocardial infarct size in rabbits after ischemic injury via elastase inhibition. -SCBT Publication Review
Date published: 2015-04-04
  • y_2021, m_7, d_30, h_19
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.18
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_203702, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 13ms
  • REVIEWS, PRODUCT