SRT1720A selective SIRT1 activator

SRT1720 (CAS 1001645-58-4)

SRT1720 | CAS 1001645-58-4 is rated 5.0 out of 5 by 1.
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Synonym: SRT 1720 Hydrochloride; N-(2-(3-(piperazin-1-ylmethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)quinoxaline-2-carboxamide hydrochloride
Application: A selective SIRT1 activator
CAS Number: 1001645-58-4
Purity: ≥98%
Molecular Weight: 506.02
Molecular Formula: C25H23N7OS•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

SRT1720 is an NAD-dependent deacetylase sirtuin-1 (SIRT1) activator (EC50 = 0.16 μM), highly selective for SIRT1 over SIRT2 or SIRT3. Studies in yeast suggest that sirtuins may be involved in epigentic gene silencing and deactylation of proteins that regulate the cell cycle.


References

1. Milne, J. C., et al. 2007. Nature. 450(7170): 712-716. PMID: 18046409

2. Chauhan, D., et al. 2011. Br. J. Haematol. 155(5): 588-598. PMID: 21950728

3. Suzuki, K., et al. 2012. Oncol. Rep. 27(6): 1726-1732. PMID: 22470132

4. Cao, L., et al. 2013. Braz. J. Med. Biol. Res. 46(8):659-669. PMID: 24036938

5. Nguyen, G. T., et al. 2013. Acta. Crystallogr. D. Biol. Crystallogr. 69(Pt 8): 1423-1432. PMID: 23897466.

6. Fan, H., et al. 2013. Kidney. Int. 83(3): 404-413. PMID: 23302720

7. Mitchell, S. J., et all. 2014. Cell Rep. 6(5): 836-843. PMID: 24582957

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water (< 1 mg/mL at 25° C), DMSO (38 mg/mL at 25° C), and ethanol (< 1 mg/mL at 25° C).
Storage :
Store at -20° C
Melting Point :
209° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
25232708
SMILES :
C1CN(CCN1)CC2=CSC3=NC(=CN23)C4=CC=CC=C4NC(=O)C5=NC6=CC=CC=C6N=C5.Cl

Download SDS (MSDS)

Certificate of Analysis

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SRT1720  Product Citations

See how others have used SRT1720. Click on the entry to view the PubMed entry .

Citations 1 to 6 of 6 total

PMID: # 30149019  Salazar-González, RA. et al. 2018. Biochem. Pharmacol. 156: 340-347.

PMID: # 30209341  Lee, J. et al. 2018. Sci Rep. 8: 13676.

PMID: # 29308302  Saidi, D.|Cheray, M.|Osman, AM.|Stratoulias, V.|Lindberg, OR.|Shen, X.|Blomgren, K.|Joseph, B.| et al. 2018. Oncoimmunology. 7: e1382790.

PMID: # 25902914  Zhao, K. et al. 2015. J Hematol Oncol. 8: 41.

PMID: # 23726949  Cheng, Y. et al. 2013. Eur. J. Pharmacol. 715: 219-29.

PMID: # 31717879  Mar Drugs. 17:

Citations 1 to 6 of 6 total

To whom it may concern, We will inject 100 mg/kg SRT1720 intraperitonally. We have PEG400, Tween80 and DMSO chemicals. Could you please help us, how can we prepare 20mg/ml clearly.&nbsp; Thanks in advance for your interestK&uuml;bra

Asked by: Kubra
Thank you for your question. We do not support in vivo use, but this biochemical is soluble in water (&lt; 1 mg/mL at 25˚C), DMSO (38 mg/mL at 25˚C), and ethanol (&lt; 1 mg/mL at 25˚C).
Answered by: Tech Service
Date published: 2019-09-24

Does SRT1720 works in every species? For example, Rat and Mouse.

Asked by: Joey1012
Thank you for your question. Yes, sc-364624 has been shown to work in mice, rat, and human. We are updating the product page on our website to include the following references: 1. Milne, J. C., et al. 2007. Nature. 450(7170): 712-716. PMID: 18046409 2. Chauhan, D., et al. 2011. Br. J. Haematol. 155(5): 588-598. PMID: 21950728 3. Suzuki, K., et al. 2012. Oncol. Rep. 27(6): 1726-1732. PMID: 22470132 4. Cao, L., et al. 2013. Braz. J. Med. Biol. Res. 46(8):659-669. PMID: 24036938 5. Nguyen, G. T., et al. 2013. Acta. Crystallogr. D. Biol. Crystallogr. 69(Pt 8): 1423-1432. PMID: 23897466. 6. Fan, H., et al. 2013. Kidney. Int. 83(3): 404-413. PMID: 23302720 7. Mitchell, S. J., et all. 2014. Cell Rep. 6(5): 836-843. PMID: 24582957
Answered by: Technical Support
Date published: 2019-09-11

What are the storage conditions necessary for this product after it has been dissolved in DMSO? How long can it be stored like this?

Asked by: Dan3009
Thank you for your question. DMSO solution is stable at 4 degree for two weeks, or can be stored at -80 degree for up to six months.
Answered by: Technical Support
Date published: 2019-05-20

What concentration should I use SRT1720 at to see activation of SIRT1?

Asked by: ChemSynth123
Thank you for your question. SRT1720 (CAS 1001645-58-4); sc-364624 is a selective SIRT1 activator with an EC50 of 0.16 &mu;M in a cell-free assay.
Answered by: Chemical Support 7
Date published: 2017-03-01
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Rated 5 out of 5 by from Chen Chen, YX. Et al. (PubMed 26296466) found that the Sirt1 activator SRT1720 attenuates angiotensin II-induced atherosclerosis in apoE(-/-) mice through inhibition of vascular inflammatory response. -SCBT Publication Review
Date published: 2015-01-26
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