SR 49059 is a potent, selective, non-peptide, orally active AVP Receptor V1a (Vasopressin V1a) antagonist. Devoid of agonist activity SR 49059 shows high affinity and efficacy at both rat (Ki = 1.6 nM) and human (Ki = 1.1-6.3 nM) V1a receptors. Potently antagonizes arginine vasopressin-induced effects in vitro.
Serradeil-Le Gal et al (1993) Biochemical and pharmacological properties of SR 49059, a new, potent, nonpeptide antagonist of rat and human vasopressin V1a receptors. J.Clin.Invest. 92 224. Serradeil-Le Gal et al (1994) Binding of [3H]SR 49059, a potent nonpeptide vasopressin V1a antagonist, to rat and human liver membranes. Biochem.Biophys.Res.Comm. 199 353. Tahtaoui et al (2003) Identification of the binding sites of the SR 49059 nonpeptide antagonist into the V1a vasopressin receptor using sulfydryl-reactive ligands and cysteine mutants as chemical sensors. J.Biol.Chem. 278 40010.
Adobe Acrobat Reader is required to reliably view, print and comment on PDF documents
bvseo_sdk, java_sdk, bvseo-3.2.0
CLOUD, getContent, 69ms
bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of
CenksoyCenksoy, C. et al. (PubMed 24405730) presented a potential novel strategy, inhibition of vasopressin-induced VEGF secretion by SR 49059, for decreasing the incidence of ovarian hyperstimulation syndrome in the hyperstimulated rat model. -SCBT Publication Review
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn
Create a new account
Email address already exists, please enter a new valid email address.Hide
USE YOUR SOCIAL NETWORK
Create an account quickly and easily with your preferred social network account. You won't have to remember an extra name and password.
Creating an account with us makes your shopping experience much easier and faster. You can save favorites, save cart, check order status and speed through checkout with saved addresses, payment methods and more.