SR 3677 dihydrochlorideA selective and potent Rho-kinase inhibitor

SR 3677 dihydrochloride (CAS 1072959-67-1 (free base))

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Synonym: N-{2-[2-(Dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl}-2,3-dihydro-1,4-benzodioxin-2-carboxamide dihydrochloride
Application: A selective and potent Rho-kinase inhibitor
CAS Number: 1072959-67-1 (free base)
Purity: ≥98%
Molecular Weight: 481.37
Molecular Formula: C22H24N4O42HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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SR 3677 dihydrochloride is a selective and potent Rho-kinase inhibitor IC50 = 3 and 56 nM for ROCK2 and ROCK1, respectively).

Physical State :
Solid
Solubility :
Soluble in water (100 mM), and DMSO (100 mM).
Storage :
Store at -20° C
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.63 (Predicted)
IC50 :
Rock-2: IC50 = 3 nM; Rock-1: IC50 = 56 nM; Akt: IC50 = 7.49 µM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
25093235
MDL Number :
MFCD20926331
SMILES :
CN(C)CCOC1=C(C=CC(=C1)C2=CNN=C2)NC(=O)C3COC4=CC=CC=C4O3.Cl.Cl

Download SDS (MSDS)

Certificate of Analysis

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