SQ-29548A potent and selective thromboxane A2 receptor antagonist

SQ-29548 (CAS 98672-91-4)

SQ-29548 | CAS 98672-91-4 is rated 5.0 out of 5 by 1.
  • y_2019, m_11, d_12, h_16
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.1
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_201332, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 103ms
  • REVIEWS, PRODUCT
5
1
4
0
3
0
2
0
1
0
Synonym: 7-[3-[[2-(phenylcarbamoyl)hydrazinyl]methyl]-7-oxabicyclo[2.2.1]heptan-2-yl]hept-5-enoic acid
Application: A potent and selective thromboxane A2 receptor antagonist
CAS Number: 98672-91-4
Purity: ≥98%
Molecular Weight: 387.47
Molecular Formula: C21H29N3O4
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

SQ-29548 is a compound that reversibly and competitively acts as a TXA2R (thromboxane A2/prostraglandin endoperoxide receptor) antagonist. Ischemic studies show that SQ 29548 significantly rescues myocardial tissue and Canine postischemic cerebral hypoperfusion studies report that SQ-29548 does not help improve postischemic cerebral hypoperfusion. SQ-29548 has been shown to bind and inhibit the thromboxane A2/prostaglandin endoperoxide receptor more potently than ONO 3708, BM 13.17, and 13-APA (sc-223165).


References

1. Kattelman, E.J., et al. 1986. Thromb. Res. 41: 471-481. PMID: 3008368
2. Olympio, M.A., et al. 1989. J Neurosurg Anesthesiol. 1: 56-62. PMID: 15815240
3. Wagerle, L.C. and Busija, D.W. 1990. Circ. Res. 66: 824-831. PMID: 2306808
4. Hunt, J.A., et al. 1992. Biochem. Pharmacol. 43: 1747-1752. PMID: 1315543
5. McMahon, T.J., et al. 1992. J. Appl. Physiol. 72: 1194-1200. PMID: 1533211
6. Singh, J., et al. 1997. Prostaglandins Leukot. Essent. Fatty Acids. 56: 105-110. PMID: 9051718
7. Graham, D.A. and Rush, J.W. 2009. J. Appl. Physiol. 107: 1059-1067. PMID: 19696359
8. Xavier, F.E., et al. 2010. Clin. Sci. 119: 283-292. PMID: 20459396
9. Malinowska, B., et al. 2010. Naunyn Schmiedebergs Arch. Pharmacol. 381: 349-360. PMID: 20198363

Usage :
Chemical can be stored as supplied for 1 year at -20° C.
Physical State :
Solid
Solubility :
Soluble in ethanol, methanol, acetonitrile, PBS pH 7.2, DMSO, dimethyl formamide , and 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin (4.7 mg/mL). Insoluble in water.
Storage :
Store at -20° C
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.58
Optical Activity :
α22/D +19.8°, c = 1.4 in methanol(lit.)
IC50 :
human platelet aggregation initiated by arachidonic acid: IC50 = 12 nM
Ki Data :
[3H]-U-46619 binding to human platelet membranes: Ki= 7.9 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
5271
MDL Number :
MFCD00153871
SMILES :
C1CC2C(C(C1O2)CC=CCCCC(=O)O)CNNC(=O)NC3=CC=CC=C3

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

SQ-29548  Product Citations

See how others have used SQ-29548. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 27382053  Feng, X. et al. 2016. J. Biol. Chem. 291: 18947-58.

Citations 1 to 1 of 1 total

What is the shipping temperature for this product?

Asked by: hawkeye11
This chemical, SQ-29548 (CAS 98672-91-4), ships on blue ice.
Answered by: Chemical Support 1
Date published: 2017-04-06
  • y_2019, m_11, d_12, h_16CST
  • bvseo_bulk, prod_bvqa, vn_bulk_3.0.1
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_1
  • loc_en_US, sid_201332, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 80ms
  • QUESTIONS, PRODUCT
Rated 5 out of 5 by from Malinowska et al Malinowska et al. (PubMed ID 20198363) used SQ-29548 to antagonize thromboxane A (2) to study thromboxane receptors' role in anandamide-induced adrenal secretion of catecholamines in urethane-anaesthetized rats. -SCBT Publication Review
Date published: 2015-06-05
  • y_2019, m_11, d_12, h_16
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.1
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_201332, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 35ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.