SQ-29548 is a compound that reversibly and competitively acts as a TXA2R (thromboxane A2/prostraglandin endoperoxide receptor) antagonist. Ischemic studies show that SQ 29548 significantly rescues myocardial tissue and Canine postischemic cerebral hypoperfusion studies report that SQ-29548 does not help improve postischemic cerebral hypoperfusion. SQ-29548 has been shown to bind and inhibit the thromboxane A2/prostaglandin endoperoxide receptor more potently than ONO 3708, BM 13.17, and 13-APA (sc-223165).
Rated 5 out of
Malinowska et alMalinowska et al. (PubMed ID 20198363) used SQ-29548 to antagonize thromboxane A (2) to study thromboxane receptors' role in anandamide-induced adrenal secretion of catecholamines in urethane-anaesthetized rats. -SCBT Publication Review
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