Spironolactone is a competitive MCR (mineralocorticoid receptor) antagonist that exhibits antihypertensive activity in vivo. Also displays antiandrogen activity and inhibits steroid hormone biosynthesis. Spironolactone is an inhibitor of AR.
Delyani et al (2000) Mineralocorticoid receptor antagonists: the evolution of utility and pharmacology. Kidney Int. 57 1408. Struthers et al (2008) A comparison of the aldosterone-blocking agents eplernone and spironolactone. Clin.Cardiol. 31 153. Ye et al (2009) Contrasting effects of eplerenone and spironolactone on adrenal cell steroidogenesis. Horm.Metab.Res. 41 35.
Soluble in water (0.022 mg/ml at 25° C), ethanol (50 mM), methanol, DMSO (100 mM), and chloroform (50 mg/ml).
Store at room temperature
207-208° C (lit.)
~597.0° C at 760 mmHg (Predicted)
~1.2 g/cm3 (Predicted)
n20D 1.59 (Predicted)
α20/D +35.2°, c = 1 in chloroform; α20/D -32--37°, c = 1 in chloroform; α20/D -37--33°, c = 1 in chloroform; α20/D -36.3°; α20/D -35.7°
bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of
Li et alLi et al. (PubMed ID 26352002) found that the mineralocorticoid receptor blocker, spironolactone, prevented cell motility by decreasing the expression of integrin beta 1 and increasing integrin beta 3 in cultured podocytes. -SCBT Publication Review
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn
Create a new account
Email address already exists, please enter a new valid email address.Hide
USE YOUR SOCIAL NETWORK
Create an account quickly and easily with your preferred social network account. You won't have to remember an extra name and password.
Creating an account with us makes your shopping experience much easier and faster. You can save favorites, save cart, check order status and speed through checkout with saved addresses, payment methods and more.