SpironolactoneA lactone for proteomic research

Spironolactone (CAS 52-01-7)

Spironolactone | CAS 52-01-7 is rated 5.0 out of 5 by 1.
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Application: A lactone for proteomic research
CAS Number: 52-01-7
Molecular Weight: 416.57
Molecular Formula: C24H32O4S
* Refer to Certificate of Analysis for lot specific data (including water content).
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Spironolactone is a competitive MCR (mineralocorticoid receptor) antagonist that exhibits antihypertensive activity in vivo. Also displays antiandrogen activity and inhibits steroid hormone biosynthesis. Spironolactone is an inhibitor of AR.


References

Delyani et al (2000) Mineralocorticoid receptor antagonists: the evolution of utility and pharmacology. Kidney Int. 57 1408. Struthers et al (2008) A comparison of the aldosterone-blocking agents eplernone and spironolactone. Clin.Cardiol. 31 153. Ye et al (2009) Contrasting effects of eplerenone and spironolactone on adrenal cell steroidogenesis. Horm.Metab.Res. 41 35.

Physical State :
Solid
Solubility :
Soluble in water (0.022 mg/ml at 25° C), ethanol (50 mM), methanol, DMSO (100 mM), and chloroform (50 mg/ml).
Storage :
Store at room temperature
Melting Point :
207-208° C (lit.)
Boiling Point :
~597.0° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.59 (Predicted)
Optical Activity :
α20/D +35.2°, c = 1 in chloroform; α20/D -32--37°, c = 1 in chloroform; α20/D -37--33°, c = 1 in chloroform; α20/D -36.3°; α20/D -35.7°
IC50 :
MCR: IC50 = 1.6 nM (human); AR: IC50 = 120 nM (human); PR: IC50 = 650 nM (human); GR: IC50 = 1.4 µM (human); CYP2C19: IC50 = 3 µM (human)
Ki Data :
MCR: Ki= 2.32 nM (human); GR: Ki= 32.6 nM (human); AR: Ki= 39.4 nM (human); PR: Ki= 399.7 nM (human); ERα: Ki>1.1 µM (human)
pK Values :
pKa: 18.01 (Predicted), pKb: -4.9 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
TU4725000
PubChem CID :
5833
Merck Index :
14: 8760
MDL Number :
MFCD00082250
EC Number :
200-133-6
Beilstein Registry :
0057767
SMILES :
CC(=O)SC1CC2=CC(=O)CC[C@]2(C)C2CC[C@@]3(C)C(CC[C@@]33CCC(=O)O3)[C@H]12

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Certificate of Analysis

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Spironolactone  Product Citations

See how others have used Spironolactone. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 27362706  Kang, SH. et al. 2016. Clin. Exp. Pharmacol. Physiol. 43: 995-1003.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Li et al Li et al. (PubMed ID 26352002) found that the mineralocorticoid receptor blocker, spironolactone, prevented cell motility by decreasing the expression of integrin beta 1 and increasing integrin beta 3 in cultured podocytes. -SCBT Publication Review
Date published: 2015-05-31
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