SPHK 1 Inhibitor 5C

SPHK 1 Inhibitor 5C (CAS 120005-55-2)

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Synonym: SKI 5C; CAY10621
Application: A selective inhibitor of SphK1
CAS Number: 120005-55-2
Purity: ≥98%
Molecular Weight: 435.64
Molecular Formula: C26H45NO4
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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SPHK 1 Inhibitor 5C is a selective inhibitor of SphK1, both in vitro (IC50 = 3.3 μM) and in U937 cells overexpressing human SphK1 (70% inhibition at 5 μM). The sphingosine kinases (SphK) phosphorylate sphingosine, producing the important lipid mediator sphingosine-1-phosphate (S1P). The two known kinases, SphK1 and SphK2, have different developmental and tissue expression patterns, suggesting that they have distinct physiological functions. Notably, SphK1 is overexpressed in several forms of cancer and inhibition of SphK1 inhibits tumor growth. It has no inhibitory effect on SphK2 either in vitro or in cells. Similarly, this chemical does not reduce the activity of protein kinase C (PKC) except at very high concentration (>75 μM).


References

1. Spiegel, S. and Milstien, S. 2007. J. Biol. Chem. 282: 2125-2129. PMID: 17135245
2. Takabe, K., et al. 2008. Pharmacol. Rev. 60: 181-195. PMID: 18552276
3. Shida, D., et al. 2008. Curr Drug Targets. 9: 662-673. PMID: 18691013
4. Wong, L., et al. 2009. J. Med. Chem. 52: 3618-3626. PMID: 19469544

Formulation :
A solution in methyl acetate
Physical State :
Liquid
Solubility :
Soluble in ethanol (~2 mg/ml), DMSO (~2 mg/ml), and DMF (~2 mg/ml).
Storage :
Store at -20° C
Boiling Point :
57° C
Refractive Index :
n20D 1.48 (Predicted)
IC50 :
SphK1: IC50 = 3.3 µM (human)
Ki Data :
SphK1: Ki= 3 µM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
Transport :
UN 1231, Class 3, Packing group II
PubChem CID :
11305122
MDL Number :
MFCD18428021
SMILES :
CCCCCCCCCCCCCC#CC(=O)[C@@H]1COC(N1C(=O)OC(C)(C)C)(C)C

Download SDS (MSDS)

Certificate of Analysis

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What does the tube look like that this inhibitor comes in?

Asked by: Cecie
Thank you for your question. This comes in a small glass vial. Please contact Technical Service by phone, (800)-457-3801 option 2, email <scbt@scbt.com>, or by live chat directly on our website, www.scbt.com if you have any further questions.
Answered by: Tech Service
Date published: 2017-06-26
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