Sphingosine Kinase InhibitorA potent, cell-permeable, non-ATP-competitive, thiazole compound

Sphingosine Kinase Inhibitor (CAS 1177741-83-1)

Sphingosine Kinase Inhibitor | CAS 1177741-83-1 is rated 5.0 out of 5 by 1.
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Synonym: 4-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]amino]phenol hydrochloride; SK1-II
Application: A potent, cell-permeable, non-ATP-competitive, thiazole compound
CAS Number: 1177741-83-1
Purity: ≥97%
Molecular Weight: 339.24
Molecular Formula: C15H11ClN2OS•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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Sphingosine Kinase Inhibitor is a potent, cell-permeable, non-ATP-competitive, thiazole compound. Is a highly specific inhibitor of SphK (sphingosine kinase) and shows anti-tumor traits.


References

French, K.J., et al. 2003. Cancer Res. 63, 5962.

Physical State :
Solid
Solubility :
Soluble in DMSO (5 mg/ml).
Storage :
Store at 4° C
Refractive Index :
n20D ~1.71 (Predicted)
IC50 :
GST-hSK: IC50 = 0.5 µM; MCRF-7/VP: IC50 = 0.9 µM; MCF-7: IC50 = 1.2 µM; NCI/ADR: IC50 = 1.3 µM; T24: IC50 = 4.6 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
16760659
SMILES :
C1=CC(=CC=C1C2=CSC(=N2)NC3=CC=C(C=C3)O)Cl.Cl

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Chatzakos et al Chatzakos et al. (PubMed ID 227279336) found that (SKI-11) sensitized liver cancer cells to cytoxic effects of selenite. -SCBT Publication Review
Date published: 2015-04-18
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