Sphingomyelin (from bovine brain)A sphingosine bonded to a fatty acid

Sphingomyelin (from bovine brain) (CAS 85187-10-6)

Sphingomyelin (from bovine brain) | CAS 85187-10-6 is rated 5.0 out of 5 by 1.
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Synonym: N-Acyl-4-sphingenyl-1-O-phosphorylcholine;N-Acyl-D-sphingosine-1-phosphocholine
Application: A sphingosine bonded to a fatty acid
CAS Number: 85187-10-6
Purity: ≥98%
Molecular Weight: 731.1 (stearoyl form)
Molecular Formula: C41H83N2O6P
* Refer to Certificate of Analysis for lot specific data (including water content).
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Sphingomyelin contains primarily stearic and nervonic acids. Structurally Sphingomyelin has a ceramide core and a sphingosine bonded to a fatty acid via an amide linkage. The compound is synthesized in the cis/medial-Golgi and is a precursor to ceramide second messengers via the action of sphingomyelinase. This is found to have a function in signal transduction. The plasma membrane of cells is highly enriched in sphingomyelin (SPH) and is considered largely to be found in the exoplasmic leaflet of the cell membrane. Transport of sphingomyelin to the cell surface has been demonstrated to occur independent of protein secretion in rat hepatocytes. It has been observed that sphyngomyelin is a key molecule for ganglioside-bound amyloid β-protein generation on the surface of PC12 cells.


References

1. Slife, C.W., et al. 1989. J. Biol. Chem. 264: 10371-10377. PMID: 2499578
2. Shiao, Y.J. and Vance, J.E. 1993. J. Biol. Chem. 268: 26085-26092. PMID: 8253724
3. Yuyama, K. and Yanagisawa, K. 2010. Neurosci. Lett. 481: 168-172. PMID: 20599476

Physical State :
Solid
Solubility :
Soluble in ethanol, chloroform, and Acetic Acid .
Storage :
Store at -20° C
pK Values :
pKa: 1.24
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
6453725
Merck Index :
14: 8746
MDL Number :
MFCD00132361
EC Number :
286-097-2
SMILES :
CCCCCCCCCCCCCCCCCC(=O)N[C@@H](COP(=O)([O-])OCC[N+](C)(C)C)[C@@H](/C=C/CCCCCCCCCCCCC)O

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Certificate of Analysis

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Sphingomyelin (from bovine brain)  Product Citations

See how others have used Sphingomyelin (from bovine brain). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 23658784  Mühle, C. et al. 2013. PLoS ONE. 8: e62912.

Citations 1 to 1 of 1 total

我需要看一眼产品包装的图片…只需有模糊的色彩分布就好…来确证一些事情…拜托(

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Date published: 2018-12-21
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Rated 5 out of 5 by from Zhou Zhou, L. et al. (PubMed 22148474) investigated the molecular species of Sphingomyelin, a sphingosine bonded to a fatty acid, in egg yolk, calf brain, ox liver, and krill oil via liquid chromatography-tandem mass spectrometry. -SCBT Publication Review
Date published: 2015-03-18
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