Sphingomyelin contains primarily stearic and nervonic acids. Structurally Sphingomyelin has a ceramide core and a sphingosine bonded to a fatty acid via an amide linkage. The compound is synthesized in the cis/medial-Golgi and is a precursor to ceramide second messengers via the action of sphingomyelinase. This is found to have a function in signal transduction. The plasma membrane of cells is highly enriched in sphingomyelin (SPH) and is considered largely to be found in the exoplasmic leaflet of the cell membrane. Transport of sphingomyelin to the cell surface has been demonstrated to occur independent of protein secretion in rat hepatocytes. It has been observed that sphyngomyelin is a key molecule for ganglioside-bound amyloid β-protein generation on the surface of PC12 cells.
1. Slife, C.W., et al. 1989. J. Biol. Chem. 264: 10371-10377. PMID: 2499578 2. Shiao, Y.J. and Vance, J.E. 1993. J. Biol. Chem. 268: 26085-26092. PMID: 8253724 3. Yuyama, K. and Yanagisawa, K. 2010. Neurosci. Lett. 481: 168-172. PMID: 20599476
Soluble in ethanol, chloroform, and Acetic Acid .
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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ZhouZhou, L. et al. (PubMed 22148474) investigated the molecular species of Sphingomyelin, a sphingosine bonded to a fatty acid, in egg yolk, calf brain, ox liver, and krill oil via liquid chromatography-tandem mass spectrometry. -SCBT Publication Review
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