Spermine, TetrahydrochlorideAn inhibitor of NOS1, NMDA, GluR, and PLCα

Spermine, Tetrahydrochloride (CAS 306-67-2)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 97ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Synonym: N,N'-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride
Application: An inhibitor of NOS1, NMDA, GluR, and PLCα
CAS Number: 306-67-2
Molecular Weight: 348.3
Molecular Formula: C10H26N44HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Spermine is a biogenic polyamine formed from spermidine (sc-215900) and occurs in almost all tissues. It is essential for both neoplastic and normal tissue growth and is involved in the modulation of calcium-dependent immune processes. Spermine inhibits NOS1 (nNOS). Spermine binds to and activates or inhibits NMDA depending on the subunit composition of the receptor. Spermine is a GluR inhibitor. Spermine is an inhibitor of PLCα and activator of PLCδ.


References

1. Pawelczyk, T., et al. 1992. Arch. Biochem. Biophys. 297: 328-333. PMID: 1497353
2. Khan, A.U., et al. 1992. Proc. Natl. Acad. Sci. U.S.A. 89: 11428-11430. PMID: 1454831
3. Escargueil-Blanc, I., et al. 1994. FASEB J. 8: 1075-1080. PMID: 7926374
4. Hu, J., et al. 1994. Neurosci. Lett. 175: 41-45. PMID: 7526294
5. Igarashi, K., et al. 1995. J. Pharmacol. Exp. Ther. 272: 1101-1109. PMID: 7891322

Physical State :
Solid
Solubility :
Soluble in water (348.2 g/l at 20° C).
Storage :
Store at room temperature
Melting Point :
310-311° C (lit.)(dec.)
Boiling Point :
308.4° C at 760 mmHg (Predicted)
Refractive Index :
n20D 1.49 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
EJ7230000
PubChem CID :
9384
Merck Index :
14: 8743
MDL Number :
MFCD00012914
EC Number :
206-189-8
Beilstein Registry :
3911771
SMILES :
C(CCNCCCN)CNCCCN.Cl.Cl.Cl.Cl

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 43ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 4ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.