Spermine is a biogenic polyamine formed from spermidine (sc-215900) and occurs in almost all tissues. It is essential for both neoplastic and normal tissue growth and is involved in the modulation of calcium-dependent immune processes. Spermine inhibits NOS1 (nNOS). Spermine binds to and activates NMDA and has been shown to potentiate NMDA-induced currents in a concentration-dependent manner. Spermine is a GluR inhibitor.
Israel, et al.: J. Med. Chem., 7, 710 (1964), Janne, J., et al.: Biochim. Biophys. Acta, 473, 241 (1978). Theoharides, T.C., et al.: Life Sci., 27, 703 (1980), Horn, Y., et al.: Cancer Res., 42, 3248 (1982),
Soluble in chloroform, methanol, water, and lower alcohols. Insoluble in ether, benzene, and petroleum ether.
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