spectrin β I Antibody (6D772): sc-73053
- spectrin β I Antibody (6D772) is a mouse monoclonal IgG1 provided at 200 µg/ml
- raised against purified erythrocyte spectrin β I of human origin
- recommended for detection of spectrin β I of mouse, rat and human origin by WB, IP and IF; non cross-reactive with spectrin α or either of the fodrin subunits
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for spectrin β I Antibody (6D772). This work is in progress.
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spectrin β I Antibody (6D772) is a mouse monoclonal IgG1 antibody that detects spectrin β I in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Spectrin β I plays a crucial role in maintaining the structural integrity and stability of the cytoskeleton in various cell types, particularly in erythrocytes, where spectrin β I forms part of the spectrin cytoskeletal network. Spectrin β I is essential for preserving the shape and deformability of red blood cells, which is vital for their function in oxygen transport and circulation. Spectrin β I interacts with spectrin α I to form heterodimers, which then assemble into higher-order structures that provide mechanical support to the plasma membrane. Additionally, spectrin β I is involved in anchoring other membrane proteins, thereby influencing cell signaling and communication. Proper functioning of spectrin β I is critical, as mutations or dysregulation can lead to various hematological disorders, highlighting spectrin β I′s importance in cellular architecture and overall cellular health. Anti-spectrin β I antibody (6D772) is an invaluable tool for researchers studying the dynamics of the cytoskeleton and its implications in health and disease.
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LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
spectrin β I Antibody (6D772) References:
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- Common and Unique Genetic Background between Attention-Deficit/Hyperactivity Disorder and Excessive Body Weight. | Dmitrzak-Weglarz, M., et al. 2021. Genes (Basel). 12: PMID: 34573389
- β2-spectrin (SPTBN1) as a therapeutic target for diet-induced liver disease and preventing cancer development. | Rao, S., et al. 2021. Sci Transl Med. 13: eabk2267. PMID: 34910547
- Identification of HSPA8 as an interacting partner of MAB21L2 and an important factor in eye development. | Seese, SE., et al. 2023. Dev Dyn. 252: 510-526. PMID: 36576422
- Tumor cell SPTBN1 inhibits M2 polarization of macrophages by suppressing CXCL1 expression. | Wu, H., et al. 2024. J Cell Physiol. 239: 97-111. PMID: 37921259
- Analysis and Verification of Glycosylation Characteristics of Septic Acute Kidney Injury. | Chen, S. and Gan, H. 2023. J Inflamm Res. 16: 5881-5897. PMID: 38076334
- Identification of candidate genes involved in Zika virus-induced reversible paralysis of mice. | Morrey, JD., et al. 2025. Sci Rep. 15: 2926. PMID: 39848964
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
spectrin β I Antibody (6D772) | sc-73053 | 200 µg/ml | $322.00 |