SPEC1 Antibody (E-2) is a mouse monoclonal IgG1 (kappa light chain) provided at 200 µg/ml
raised against amino acids 39-79 mapping at the C-terminus of SPEC1 of human origin
SPEC1 Antibody (E-2) is recommended for detection of SPEC1 isoform α of mouse, rat and human origin by WB, IP, IF and ELISA
SPEC1 Antibody (E-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
See m-IgGκ BP-HRP (mouse IgGκ binding protein-HRP), our highly recommended recombinant alternative to conventional secondary anti-mouse IgG reagents.
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of SPEC1 (E-2): sc-514978.
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Rho GTPases are molecular switches that regulate many essential cellular processes, including Actin dynamics, cell adhesion, cell-cycle progression and transcription. Cdc42, a small GTPase, regulates Actin polymerization, elongation of cell shape and cell signaling through interactions with many different downstream effector proteins, most of which contain a Cdc42-binding motif known as a CRIB domain. SPEC1 (small protein effector 1 of Cdc42), also known as CDC42SE1 (CDC42 small effector 1) or SCIP1, is a 79 amino acid cytoplasmic protein that may participate in the organization of the Actin cytoskeleton by acting downstream of Cdc42, thereby inducing Actin filament assembly and inducing cell shape changes. SPEC1 may also be involved in Cdc42-mediated F-actin accumulation at the immunological synapse of activated T-cells and may function in early contractile events during phagocytosis in macrophages. Containing a CRIB domain and a member of the Cdc42SE/SPEC family, SPEC1 is widely expressed and exists as two alternatively spliced isoforms.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
I need to use an antibody to detect the protein in samples of monkey origin. Do you know if sc-514978: SPEC1 (E-2) mouse monoclonal antibody will work?
Asked by: cjMara
Please contact our Technical Service Department and we would be happy to perform sequence analysis and review our data to answer any questions you may have about additional species reactivity.
Answered by: Technical Support
Date published: 2017-03-06
Is it possible to give samples of this antibody before we buy
Asked by: Pazhani
Thank you for your question. We are currently offering a limited time promotion and can provide you with a complimentary 10 µg sample of this mouse monoclonal antibody, SPEC1 (E-2): sc-514978. Please contact our Technical Service Department directly for more information. Please call us directly at (800) 457-3801 option 2, or email email@example.com. Alternatively, please contact one of our authorized distributors in Singapore. A link to search for our regional distributors is provided below.
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn
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