SparfloxacinA broad spectrum fluoroquinolone antibiotic

Sparfloxacin (CAS 110871-86-8)

Sparfloxacin | CAS 110871-86-8 is rated 5.0 out of 5 by 1.
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Synonym: Zagam
Application: A broad spectrum fluoroquinolone antibiotic
CAS Number: 110871-86-8
Purity: ≥98%
Molecular Weight: 392.40
Molecular Formula: C19H22F2N4O3
* Refer to Certificate of Analysis for lot specific data (including water content).
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Sparfloxacin is a fluoroquinolone with broad spectrum antibacterial activity against Gram-positive and Gram-negative bacteria. Inhibits bacterial DNA gyrase (topoisomerase). Effective against Mycobacterium tuberculosis. Shows photosensitizing effects. Sparfloxacin is an inhibitor of Topo II.


References

1. Nakamura, S., et al. 1989. Antimicrob. Agents Chemother. 33: 1167-1173. PMID: 2802544
2. Miyamoto, T., et al. 1990. J. Med. Chem. 33: 1645-1656. PMID: 2342057
3. Nakamura, S., et al. 1990. Antimicrob. Agents Chemother. 34: 89-93. PMID: 2327763

Physical State :
Solid
Solubility :
Soluble in water (<1 mg/ml), 100% ethanol, chloroform, methanol, and DMSO (9 mg/ml).
Storage :
Store at -20° C
Melting Point :
265° C
Boiling Point :
~640.4° C at 760 mmHg (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.63 (Predicted)
IC50 :
DNA gyrase: IC50 = 0.64 µM (Escherichia coli K-12); Nucleic Acid: IC50 = 17.5 µM; HERG: IC50 = 18.20 µM (human); V79: IC50 = 94.2 µM (Cricetulus griseus)
Ki Data :
HERG: Ki= 38.62 µM (human)
pK Values :
pKa: 6.42 (Predicted), pKb: 8.59 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
VB1986500
PubChem CID :
60464
Merck Index :
14: 8735
MDL Number :
MFCD00869619
Beilstein Registry :
9170271
SMILES :
C[C@@H]1CN(C[C@@H](N1)C)C2=C(C3=C(C(=C2F)N)C(=O)C(=CN3C4CC4)C(=O)O)F

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Beberok et al Beberok et al. (PubMed ID 25560573) found that Sparfloxacin inhibited melanogensis and changes in antioxidant enzymes in human melanocytes. -SCBT Publication Review
Date published: 2015-06-20
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