Sp-cAMPS, a stimulatory diastereoisomer of adenosine 3',5'-(cyclic)phosphorothioate, has been shown to contain an axial exocyclic sulphur atom. Experiments have noted that this agent binds to holoenzymes, releases its catalytic subunit and activates phosphotransferase and cAMP-dependent protein kinase activity. Additionally, Sp-cAMPS has demonstrated the ability to mimick glucagon-stimulated increases in the level of Ca2+ in hepatocytes.
1. Braumann, T., et al. 1986. Biochim. Biophys. Acta. 871: 199-206. PMID: 3011099 2. Connelly, P.A., et al. 1987. J. Biol. Chem. 262: 4324-4332. PMID: 3031072 3. Rothermel, J.D., et al. 1988. Biochem. J. 251: 757-762. PMID: 2843164
Store, as supplied, at -20°C for up to one year. Store solutions at -20°C for up to 3 months.
Soluble in water (25 mg/mL), DMSO, DMF, and methanol.
Store at -20° C
641.7° C at 760 mmHg (Predicted)
α22/D -25.43°, c = 0.99 in water(lit.)
pKa: 1 (Predicted), pKb: 3.63 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Rated 5 out of
MenezesMenezes, et al. (PubMed ID 25775606) found that Sp-cAMP counteracts the effect of D1/D5 dopaminergic antagonist SCH 23390 on hippocampal dopamine levels in rats. -SCBT Publication Review
To place an order using RMB or to ship to mainland China, please visit www.scbio.cn
You may not log in without verifying your email address. Please check your email (including your spam email) for the Welcome message that was sent.
Create a new account
Email address already exists, please enter a new valid email address.
USE YOUR SOCIAL NETWORK
Create an account quickly and easily with your preferred social network account. You won't have to remember an extra name and password.
Creating an account with us makes your shopping experience much easier and faster. You can save favorites, save cart, check order status and speed through checkout with saved addresses, payment methods and more.
Already have an account?
Please check your email (including your spam email) for a Welcome message, and verify your email address to continue.