Sp-cAMPS, a stimulatory diastereoisomer of adenosine 3',5'-(cyclic)phosphorothioate, has been shown to contain an axial exocyclic sulphur atom. Experiments have noted that this agent binds to holoenzymes, releases its catalytic subunit and activates phosphotransferase and cAMP-dependent protein kinase activity. Additionally, Sp-cAMPS has demonstrated the ability to mimick glucagon-stimulated increases in the level of Ca2+ in hepatocytes.
1. Braumann, T., et al. 1986. Biochim. Biophys. Acta. 871: 199-206. PMID: 3011099 2. Connelly, P.A., et al. 1987. J. Biol. Chem. 262: 4324-4332. PMID: 3031072 3. Rothermel, J.D., et al. 1988. Biochem. J. 251: 757-762. PMID: 2843164
Store, as supplied, at -20°C for up to one year. Store solutions at -20°C for up to 3 months.
Soluble in water (25 mg/mL), DMSO, DMF, and methanol.
Store at -20° C
641.7° C at 760 mmHg (Predicted)
α22/D -25.43°, c = 0.99 in water(lit.)
pKa: 1 (Predicted), pKb: 3.63 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Rated 5 out of
MenezesMenezes, et al. (PubMed ID 25775606) found that Sp-cAMP counteracts the effect of D1/D5 dopaminergic antagonist SCH 23390 on hippocampal dopamine levels in rats. -SCBT Publication Review
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