Sp-5,6-DCI-cBiMPSCAS: 120912-54-1
MF: C12H10Cl2N2O5PS•Na
MW: 419.2
Potent activator of PKA.
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Sp-5,6-DCI-cBiMPS (CAS 120912-54-1)

Sp-5,6-DCI-cBiMPS | CAS 120912-54-1 is rated 5.0 out of 5 by 1.
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See product citations (5)
Application: Potent activator of PKA
CAS Number: 120912-54-1
Purity: ≥98%
Molecular Weight: 419.2
Molecular Formula: C12H10Cl2N2O5PS•Na
* Refer to Certificate of Analysis for lot specific data (including water content).
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Sp-5,6-DCI-cBiMPS is a phosphodiesterase-sensitive cAMP analog and potent activator of PKA (cAMP-dependent protein kinase). It has been tested to be cell permeable and resists hydrolysis from type I, II, and III phosphodiesterases. Observed to stop the aggregation induced by thrombin and initiated protein phosphorylation induced by prostaglandin E1 in human platelets. When applied extracellulary to T84 human colon cancer cells in vitro, Sp-5,6-DCI-cBiMPS was shown to be a potent activator of Cl- secretion. Practical in experiments distinguishing between cAMP and cGMP signal transduction pathways.


References

1. Sandberg, M., et al. 1991. Biochem. J. 279: 521-527. PMID: 1659381
2. Schultz, C., et al. 1994. Mol. Pharmacol. 46: 702-708. PMID: 7969049
3. Chen, J., et al. 2009. Reproduction. 138: 759-770. PMID: 19700529

Physical State :
Solid
Solubility :
Soluble in water (1 mM), 96% ethanol (167 mM), DMSO (167 mM), dimethyl formamide (167 mM), methanol (25 mM), phostphate buffered saline (pH 7.4) (1.4 mM), 25 mM TRIS (pH 7.4) (25 mM), 25 mM HEPES (pH 7.2) (35.7 mM), and Na2HPO4.
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
23675379
MDL Number :
MFCD06795834
SMILES :
C1[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=NC4=CC(=C(C=C43)Cl)Cl)O)OP(=S)(O1)[O-].[Na+]

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Certificate of Analysis

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Sp-5,6-DCI-cBiMPS  Product Citations

See how others have used Sp-5,6-DCI-cBiMPS. Click on the entry to view the PubMed entry .

Citations 1 to 5 of 5 total

PMID: # 31059522  Paul, P.|Ramachandran, S.|Xia, S.|Unruh, JR.|Conkright-Fincham, J.|Li, R.| et al. 2019. PLoS ONE. 14: e0216220.

PMID: # 16219670  Gambaryan, S. et al. 2006. Am J Physiol Endocrinol Metab. 290(3): E423-33.

PMID: # 15572160  Kidokoro, Y. et al. 2004. Brain Res. Brain Res. Rev. 47: 18-32.

PMID: # 11170272  Loir, M. et al. 2001. Mol. Reprod. Dev. 58: 307-317.

PMID: # 8384208  Schaap, P. et al. 1993. J. Biol. Chem. 268: 6323-6331.

Citations 1 to 5 of 5 total
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Rated 5 out of 5 by from Gambaryan et al (PubMed ID 16219670) used Gambaryan et al (PubMed ID 16219670) used the cAMP analog and PKA activator, Sp-5, 6-DCI-cBIMPS (cBIMPS), as a negative control to study the forskolin-stimulated aldosterone production independent of PKA activity. -SCBT Publication Review
Date published: 2015-02-04
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