Sotalol hydrochlorideCAS: 959-24-0
MF: C12H20N2O3S•HCl
MW: 308.82
A potent β adrenergic antagonist.

Sotalol hydrochloride (CAS 959-24-0)

Sotalol hydrochloride | CAS 959-24-0 is rated 5.0 out of 5 by 1.
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Application: A potent β adrenergic antagonist
CAS Number: 959-24-0
Purity: ≥99%
Molecular Weight: 308.82
Molecular Formula: C12H20N2O3S•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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Sotalol hydrochloride is a compound categorized with class III antiarrhythmic activity with a mechanism of action that prolongs the action potential and refraction of cardiac tissue through non-selective yet potent β-adronergic blocking activity. Sotalol hydrochloride is also considered a non-selective β blocker and a potassium channel blocker with an IC50 of 43 µM.


References

1. Zanetti, L.A. 1993. Clin Pharm. 12: 883-891. PMID: 8137605
2. Claudel, J.P. and Touboul, P. 1995. Pacing Clin Electrophysiol. 18: 451-467. PMID: 7770366
3. Bauman, J.L. 1997. Pharmacotherapy. 17: 76S-83S; discussion 89S. PMID: 9085343

Physical State :
Solid
Solubility :
Soluble in phosphate buffered saline (100 mM), DMSO (62 mg/ml at 25° C), ethanol (<1 mg/ml at 25° C), water (62 mg/ml at 25° C), and methanol.
Storage :
Store at room temperature
Melting Point :
206.5-207° C
Boiling Point :
443.3° C at 760
Refractive Index :
n20D 1.57 (Predicted)
IC50 :
Adrenergic receptor β: IC50 = 7.2 µM (human); Potassium channel : IC50 = 43 µM
Ki Data :
Beta adrenoceptor: Ki= 0.93 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
PB0826000
PubChem CID :
66245
Merck Index :
14: 8728
MDL Number :
MFCD00242937
EC Number :
213-496-0
SMILES :
CC(C)NCC(C1=CC=C(C=C1)NS(=O)(=O)C)O.Cl

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Bauman (PubMed ID 9085343) used sotalol hydrochloride Bauman (PubMed ID 9085343) used sotalol hydrochloride to treat ventricular arrhythmias and found it to block beta-adrenergic receptors. -SCBT Publication Review
Date published: 2015-04-10
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