Sos SH3 domain inhibitor CAS: 159088-48-9
MF: C53H91N19O11
MW: 1170.43
A synthetic inhibitor for Sos.

Sos SH3 domain inhibitor (CAS 159088-48-9)

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Alternate Names: Ras inhibitory peptide; VPPPVPPRRR; SOS-1 (human) (1149-1158)
Application: Sos SH3 domain inhibitor is blocks Sos/GRB2 interaction, preventing Ras activation
CAS Number: 159088-48-9
Purity: ≥97%
Molecular Weight: 1170.43
Molecular Formula: C53H91N19O11
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Sos SH3 domain inhibitor is a biologically active peptide. The SH3 binding sequence of Sos which blocks Sos/GRB2 interaction, preventing Ras activation via receptor protein tyrosine kinases.


References

1. Goudreau, N., et al., 1994. NMR structure of the N-terminal SH3 domain of GRB2 and its complex with a proline-rich peptide from Sos. Nature structural biology. 1(12): 898-907. PMID: 7773779
2. Li, N., et al., 1993. Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling. Nature. 363(6424): 85-8. PMID: 8479541
3. Vidal, M., et al., 2004. Design of peptoid analogue dimers and measure of their affinity for Grb2 SH3 domains. Biochemistry. 43(23): 7336-44. PMID: 15182177
4. Jacquot, Yves., et al., 2007. High affinity Grb2-SH3 domain ligand incorporating Cbeta-substituted prolines in a Sos-derived decapeptide. Bioorganic & medicinal chemistry. 15(3): 1439-47. PMID: 17113302
5. Ho, Pei-Yin., et al., 2006. Terbinafine inhibits endothelial cell migration through suppression of the Rho-mediated pathway. Molecular cancer therapeutics. 5(12): 3130-8. PMID: 17172416

Appearance :
Lyophilized powder
Physical State :
Solid
Sequence :
Val-Pro-Pro-Pro-Val-Pro-Pro-Arg-Arg-Arg
Solubility :
Soluble in water.
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Download SDS (MSDS)

Certificate of Analysis

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Sos SH3 domain inhibitor (CAS 159088-48-9)  Product Citations

See how others have used Sos SH3 domain inhibitor (CAS 159088-48-9). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 21067705  2011. Microvasc. Res. 81: 135-42.

Citations 1 to 1 of 1 total

Hi, I'm wondering whether sc-3124:Sos SH3 domain inhibitor is cell permeable? Can it work in cells? Thank you!

Asked by: Ruoyu
Thank you for your question. We could not find any information supporting that sc-3124 is cell permeable. We have found journal articles indicating that Sos SH3 domain inhibitor has been shown to inhibit GRB2/SOS interaction in CD34+ cells. Please refer to PubMed, PMID: 3327923.
Answered by: Technical Support
Date published: 2019-08-26
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