Anti-Sos 1 Antibody (A-9) is a mouse monoclonal IgG2b κ Sos 1 antibody, cited in 5 publications, provided at 200 µg/ml
raised against amino acids 1057-1178 mapping near the C-terminus of Sos 1 of human origin
Anti-Sos 1 Antibody (A-9) is recommended for detection of Sos 1 of mouse, rat and human origin by WB, IP, IF and ELISA
Anti-Sos 1 Antibody (A-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of Sos 1 (A-9): sc-17793.
m-IgG2b BP-HRP is the preferred secondary detection reagent for Sos 1 Antibody (A-9) for WB applications. This reagent is now offered in a bundle with Sos 1 Antibody (A-9) (see ordering information below).
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
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Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Sos 1 Antibody (A-9) is a high quality monoclonal Sos 1 antibody (also designated SOS Ras/Rac Guanine Nucleotide Exchange Factor 1 antibody, Gingival Fibromatosis Hereditary 1 antibody, Son Of Sevenless Homolog 1 antibody, SOS-1 antibody, GF1 antibody, HGF antibody, Son Of Sevenless Homolog 1 (Drosophila) antibody, Guanine Nucleotide Exchange Factor antibody, GINGF antibody, or GGF1 antibody) suitable for the detection of the Sos 1 protein of mouse, rat and human origin. Sos 1 Antibody (A-9) is available as both the non-conjugated anti-Sos 1 antibody form, as well as multiple conjugated forms of anti-Sos 1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The superfamily of GTP-binding proteins, of which Ras proteins are prototypes, has been implicated in a broad range of biological activities. Studies have identified a family of guanine nucleotide-releasing factors (GRFs) that activate Ras in mammalian cells and an "adapter" protein (Sem 5/GRB2) that appears to mediate the interaction of GRFs with activated receptor molecules. Ras-GRF p140 promotes nucleotide exchange on ras p21s but not on other members of the Ras gene superfamily. In addition, three mammalian homologs of the Drosophila Ras-GRF, son of sevenless (Sos), have been described. These include two from mouse, m Sos 1 and m Sos 2, and one from human, h Sos. Vav p95 has been reported to function as a GRF in activation of Ras by the T cell receptor and has been reported to have a domain similar to that of Dbl p115, which is a GRF specific for CDC42Hs. Subsequent to activation, Ras appears to interact with Raf, thereby activating the MAP kinase phosphorylation pathway.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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