An antifungal metabolite possessing a tetracyclic diterpene glycoside structure. It is a highly potent inhibitor of eukaryotic protein synthesis with selectivity for the fungal translation machinery. The elongation factor eEF-2 is the molecular target for sordarin. It blocks ribosomal translocation by stabilizing the EF2-ribosome complex in a manner similar to that of fusidic acid in the bacterial system. Additional cellular components (including rpP0, which is an essential protein of the ribosomal large subunit stalk) are involved in its mechanism of action. Sordarin inhibits in vitro translation in the pathogenic fungi C. albicans, C. glabrata, and C. neoformans. In addition to its therapeutic potential, sordarin is a useful tool for the analysis of protein translation events.
Soluble in a minimum of 10 mg/ml water
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Rated 5 out of
Dom nguezDom nguez, JM. et al. (PubMed 10428815) reported that Sordarin inhibits fungal protein synthesis by blocking translocation differently to fusidic acid. -SCBT Publication Review
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