Sodium dodecyl sulfateAn anionic detergent and protein denaturant

Sodium dodecyl sulfate (CAS 151-21-3)

Sodium dodecyl sulfate | CAS 151-21-3 is rated 5.0 out of 5 by 1.
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Synonym: SDS; Sodium lauryl sulfate
Application: An anionic detergent and protein denaturant
CAS Number: 151-21-3
Purity: ≥96%
Molecular Weight: 288.38
Molecular Formula: C12H25O4S•Na
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Sodium dodecyl sulfate (SDS) is an anionic detergent used to solubilize and denature proteins in protein extraction and SDS-PAGE; also used in a variety of hybridization and molecular biology techniques. SDS is effective in both ionic and anionic conditions. SDS unravels proteins by binding to peptide chains and imparting a negative charge on the protein; this causes the protein to unfold eliminating shape as a factor for gel separation.

Also available in solution form: SDS (20% Solution) (sc-24950).


References

1. Laemmli, U.K. 1970. Nature. 227: 680-685. PMID: 5432063
2. Weber, K. and Kuter, D.J. 1971. J. Biol. Chem. 246: 4504-4509. PMID: 5106387
3. Harewood, K. and Wolff, J.S. 1973. Anal. Biochem. 55: 573-581. PMID: 4201521
4. Hayashi, K. 1975. Anal. Biochem. 67: 503-506. PMID: 1163770
5. Kapp, O.H. and Vinogradov, S.N. 1978. Anal. Biochem. 91: 230-235. PMID: 9762103
6. Womack, M.D., et al. 1983. Biochim. Biophys. Acta. 733: 210-215. PMID: 6882760
7. Grohs, R.A., et al. 1991. Anal. Chem. 63: 384-390. PMID: 1823727
8. Gallagher, S.R. 2007. Curr Protoc Cell Biol. 6: 6.1. PMID: 18228518

Appearance :
Crystalline
Physical State :
Solid
Solubility :
Soluble in water (150 g/L) at 20° C, and ethanol (partly soluble).
Storage :
Store at room temperature
Melting Point :
204-207° C (lit.)
IC50 :
Human HepG2/C3A cells: IC50 = 0.22 nM
Ki Data :
Displacement of C18-Aib-lucifer yellow from HIV1 envelope glycoprotein gp41 Fe(env2.0)3 receptor: Ki= 2000 nM
pK Values :
pKa: -3.29 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
2
RTECS :
WT1050000
Transport :
UN 2926, Class 4.1 (6.1), Packing group II
PubChem CID :
3423265
Merck Index :
14: 08636
MDL Number :
MFCD00036175
EC Number :
205-788-1
Beilstein Registry :
3599286
SMILES :
CCCCCCCCCCCCOS(=O)(=O)[O-].[Na+]

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Sodium dodecyl sulfate  Product Citations

See how others have used Sodium dodecyl sulfate. Click on the entry to view the PubMed entry .

Citations 1 to 7 of 7 total

PMID: # 27038753  Aligholi, H. et al. 2016. Brain research. 1642: 197-208.

PMID: # 26780454  Karimzadeh, F. et al. 2016. Mol. Neurobiol.

PMID: # 26141394  Wan, D. et al. 2015. Toxicol. Sci. 147: 326-38.

PMID: # 24962405  Ahn, JH. et al. 2014. J. Vet. Sci. 15: 335-42.

PMID: # 22245848  Ahmad, J. et al. 2012. Toxicol. Appl. Pharmacol. 259: 160-8.

PMID: # 22393286  Akhtar, MJ. et al. 2012. Int J Nanomedicine. 7: 845-57.

PMID: # 21606120  2011. Mol. Hum. Reprod. 17: 693-701.

Citations 1 to 7 of 7 total
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Rated 5 out of 5 by from Various publications cite the use of Sodium Various publications cite the use of Sodium dodecyl sulfate to solubilize and denature proteins in SDS-PAGE gel electrophoresis and for protein extraction applications. -SCBT Publication Review
Date published: 2015-01-06
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