SMI-4aAn inhibitor of Pim-1 and Pim-2

SMI-4a (CAS 327033-36-3)

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Synonym: 5-{[3-(trifluoromethyl)phenyl]methylidene}-1,3-thiazolidine-2,4-dione
Application: An inhibitor of Pim-1 and Pim-2
CAS Number: 327033-36-3
Purity: ≥95%
Molecular Weight: 273.2
Molecular Formula: C11H6F3NO2S
* Refer to Certificate of Analysis for lot specific data (including water content).
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SMI-4a is a selective inhibitor of the protein kinases, Pim-1 and Pim-2. Induces apoptosis by way of the mitochondrial pathway. Induces G1 phase cell cycle arrest. Inhibits rapamycin C1 (mTORC1) pathway. Inhibits phosphorylation of PRAS40 and mTOR activity. Downregulates c-myc.

Physical State :
Solid
Solubility :
Soluble in DMSO (≥ 5 mg/ml).
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
1361332
SMILES :
C1=CC(=CC(=C1)C(F)(F)F)/C=C/2\C(=O)NC(=O)S2

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Certificate of Analysis

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