SMC Proliferation Inhibitor-2wA diarly amide analog

SMC Proliferation Inhibitor-2w (CAS 343783-87-9)

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Synonym: ethyl 4,5-dimethoxy-2-[(3,4,5-trimethoxybenzoyl)amino]benzoate
Application: A diarly amide analog
CAS Number: 343783-87-9
Molecular Weight: 419.43
Molecular Formula: C21H25NO8
* Refer to Certificate of Analysis for lot specific data (including water content).
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SMC Proliferation Inhibitor-2w is a diaryl amide analog that exhibits about 15 fold greater selectivity in inhibiting the proliferation of human coronary artery smooth muscle cells over the endothelial cells.


References

1. Ogita, H., et al., 2001. Synthesis and structure-activity relationship of diarylamide derivatives as selective inhibitors of the proliferation of human coronary artery smooth muscle cells. Bioorganic & medicinal chemistry letters. 11(4): 549-51. PMID: 11229768

Physical State :
Solid
Solubility :
Soluble in DMSO (5 mg/ml).
Storage :
Store at -20° C
Melting Point :
239.57° C (Predicted)
Boiling Point :
515.97° C at 760 mmHg (Predicted)
Density :
1.22 g/cm3 (Predicted)
Refractive Index :
n20D 1.56 (Predicted)
IC50 :
Proliferation of human coronary artery smooth muscle cells: IC50 = 0.31 µM; Proliferation of endothelial cells: IC50 = 4.6 µM
pK Values :
pKa: 11.22 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
9931877
MDL Number :
MFCD18803657
SMILES :
CCOC(=O)C1=CC(=C(C=C1NC(=O)C2=CC(=C(C(=C2)OC)OC)OC)OC)OC

Download SDS (MSDS)

Certificate of Analysis

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