SMC Proliferation Inhibitor-2w is a diaryl amide analog that exhibits about 15 fold greater selectivity in inhibiting the proliferation of human coronary artery smooth muscle cells over the endothelial cells.
1. Ogita, H., et al., 2001. Synthesis and structure-activity relationship of diarylamide derivatives as selective inhibitors of the proliferation of human coronary artery smooth muscle cells. Bioorganic & medicinal chemistry letters. 11(4): 549-51. PMID: 11229768
Soluble in DMSO (5 mg/ml).
Store at -20° C
239.57° C (Predicted)
515.97° C at 760 mmHg (Predicted)
1.22 g/cm3 (Predicted)
n20D 1.56 (Predicted)
Proliferation of human coronary artery smooth muscle cells: IC50 = 0.31 µM; Proliferation of endothelial cells: IC50 = 4.6 µM
pKa: 11.22 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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