SK&F 97541 SK&F 97541 is a very potent GABAB agonist/GABAC antagonist.

SK&F 97541 (CAS 127729-35-5)

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Alternate Names: 3-aminopropyl(methyl)phosphinic acid
Application: SK&F 97541 is a very potent GABAB agonist/GABAC antagonist
CAS Number: 127729-35-5
Purity: 98%
Molecular Weight: 137.1
Molecular Formula: C4H12NO2P
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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SK&F 97541 is a very potent GABAB agonist, at least ten times more active than baclofen. It is also known to act as a GABAC antagonist. It evokes concentration-dependent hyperpolarization and depresses excitatory postsynaptic potentials. SK&F 97541 is an inhibitor of GABAA R rho 1.


References

1. Seabrook, G.R., et al. 1990. Br. J. Pharmacol. 101: 949-957. PMID: 1964824

2. Froestl, W., et al. 1995. J. Med. Chem. 38: 3297-3312. PMID: 7650684

3. Bon, C., et al. 1996. Br. J. Pharmacol. 118: 961-967. PMID: 8799569

4. Johnston, G.A. 1996. Trends Pharmacol. Sci. 17: 319-323. PMID: 8885697

Usage :
Store, as supplied, at room temperature for up to 1 year. Store solutions at - 20°C for up to 3 months.
Physical State :
Solid
Solubility :
Soluble in water (100 mM).
Storage :
Store at room temperature
Melting Point :
41.22° C (Predicted)
Boiling Point :
~375.4° C at 760 mmHg (Predicted)
Density :
~1.1 g/cm3 (Predicted)
Refractive Index :
n20D 1.46 (Predicted)
IC50 :
GABA B receptor: IC50 = 0.016 nM (rat); GABA-B receptor 1: IC50 = 16 nM (rat); depression of striatal synaptic potentials: EC5050 = 920 nM
Ki Data :
Displacement of [3H]GABA from GABABreceptor: Ki= 33 nM (rat)
pK Values :
pKa: 2.65 (Predicted), pKb: 10.43 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
SZ4129300
PubChem CID :
MDL Number :
MFCD00209879
SMILES :
CP(=O)(CCCN)O

Download SDS (MSDS)

Certificate of Analysis

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