SKF 81297 hydrobromideAn agonist of the D1DR

SKF 81297 hydrobromide (CAS 71636-61-8)

SKF 81297 hydrobromide | CAS 71636-61-8 is rated 5.0 out of 5 by 1.
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Synonym: (±)-6-Chloro-PB hydrobromide
Application: An agonist of the D1DR
CAS Number: 71636-61-8
Purity: ≥98%
Molecular Weight: 370.67
Molecular Formula: C16H16ClNO2•HBr
* Refer to Certificate of Analysis for lot specific data (including water content).
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SKF 81297 hydrobromide is a full D1-like dopamine receptor agonist used in the study of the effects of d-amphetamine. SFK 81297 has shown a 25-fold greater efficacy for stimulating adenylate cyclase, the enzyme that synthesizes cAMP from ATP. SKF 81297 hydrobromide is an activator of D1DR.


References

1. Nielsen, E.B., et al. 1989. Eur. J. Pharmacol. 160: 253-262. PMID: 2569406
2. Peacock, L., et al. 1990. Eur. J. Pharmacol. 186: 49-59. PMID: 1980891
3. Andersen, P.H. and Jansen, J.A. 1990. Eur. J. Pharmacol. 188: 335-347. PMID: 1973652
4. Arnt, J., et al. 1992. Eur. J. Pharmacol. 213: 259-267. PMID: 1355737
5. Reavill, C., et al. 1993. Behav Pharmacol. 4: 135-146. PMID: 11224180

Physical State :
Solid
Solubility :
Soluble to 100 mM in DMSO
Storage :
Desiccate at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
11957706
MDL Number :
MFCD00153782
SMILES :
C1CNCC(C2=CC(=C(C(=C21)Cl)O)O)C3=CC=CC=C3.Br

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Certificate of Analysis

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Please share the mu agonist catagory

Asked by: Midnight raven
Thank you for your question. We do not have any information about your question. This chemical is for research use only. Not intended for diagnostic or therapeutic use.
Answered by: Technical Support
Date published: 2019-10-25
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Rated 5 out of 5 by from Gangarossa Gangarossa, G. et al. (25044816) found that repeated stimulation of dopamine D1-like receptor by SKF 81297 and hyperactivation of mTOR signaling lead to generalized seizures, altered dentate gyrus plasticity, and memory deficits in mice. -SCBT Publication Review
Date published: 2015-06-23
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