SKF 81297 hydrobromide is a full D1-like dopamine receptor agonist used in the study of the effects of d-amphetamine. SFK 81297 has shown a 25-fold greater efficacy for stimulating adenylate cyclase, the enzyme that synthesizes cAMP from ATP. SKF 81297 hydrobromide is an activator of D1DR.
1. Nielsen, E.B., et al. 1989. Eur. J. Pharmacol. 160: 253-262. PMID: 2569406 2. Peacock, L., et al. 1990. Eur. J. Pharmacol. 186: 49-59. PMID: 1980891 3. Andersen, P.H. and Jansen, J.A. 1990. Eur. J. Pharmacol. 188: 335-347. PMID: 1973652 4. Arnt, J., et al. 1992. Eur. J. Pharmacol. 213: 259-267. PMID: 1355737 5. Reavill, C., et al. 1993. Behav Pharmacol. 4: 135-146. PMID: 11224180
Soluble to 100 mM in DMSO
Desiccate at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Please share the mu agonist catagory
Asked by: Midnight raven
Thank you for your question. We do not have any information about your question. This chemical is for research use only. Not intended for diagnostic or therapeutic use.
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GangarossaGangarossa, G. et al. (25044816) found that repeated stimulation of dopamine D1-like receptor by SKF 81297 and hyperactivation of mTOR signaling lead to generalized seizures, altered dentate gyrus plasticity, and memory deficits in mice. -SCBT Publication Review
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