SKF 38393 hydrochloride is a benzazepine selective agonist of the D1DR (dopamine D1 receptor). Agonism of the D1DR by SKF 38393 is correlated to induced desynchronization of electroencephalographic activity in rats. SKF 38393 is also reported to demonstrate agonism of the serotonin SR-2C (5-HT1C receptor). SKF 38393 HCl is an activator of D5DR.
1. Ongini, E., et al. 1985. Life Sci. 37: 2327-2333. PMID: 3877855 2. Briggs, C.A., et al. 1991. Br. J. Pharmacol. 104: 1038-1044. PMID: 1687364 3. Katz, J.L. and Witkin, J.M. 1992. Psychopharmacology. 107: 217-220. PMID: 1352052
Soluble in DMSO (10 mg/ml), and 0.1N HCl (5 mg/ml). Insoluble in water, and ethanol.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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ShenShen, MY. et al. (PubMed 25444866) investigated the effects of D1-D2 heteromer stimulation by the agonist SKF 83959 and its disruption by a selective TAT-D1 peptide on amphetamine-induced locomotor sensitization. They found that the dopamine D1-D2 receptor heteromer exerts a tonic inhibitory effect on the expression of amphetamine-induced locomotor sensitization. -SCBT Publication Review
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