SKF 38393 hydrochlorideA benzazepine selective agonist of D1DR

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SKF 38393 hydrochloride (CAS 62717-42-4)

SKF 38393 hydrochloride | CAS 62717-42-4 is rated 5.0 out of 5 by 1.

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Synonym: (±)-1-Phenyl-2,3,4,5-tetrahydro-(1H)-3-benzazepine-7,8- diol hydrobromide

Application: A benzazepine selective agonist of D1DR

CAS Number: 62717-42-4

Purity: ≥97%

Molecular Weight: 291.77

Molecular Formula: C₁₆H₁₇NO₂•HCl

* Refer to Certificate of Analysis for lot specific data (including water content).

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SKF 38393 hydrochloride is a benzazepine selective agonist of the D1DR (dopamine D₁ receptor). Agonism of the D1DR by SKF 38393 is correlated to induced desynchronization of electroencephalographic activity in rats. SKF 38393 is also reported to demonstrate agonism of the serotonin SR-2C (5-HT_1C receptor). SKF 38393 HCl is an activator of D5DR.

References

1. Ongini, E., et al. 1985. Life Sci. 37: 2327-2333. PMID: 3877855
2. Briggs, C.A., et al. 1991. Br. J. Pharmacol. 104: 1038-1044. PMID: 1687364
3. Katz, J.L. and Witkin, J.M. 1992. Psychopharmacology. 107: 217-220. PMID: 1352052

Physical State :

Solid

Solubility :

Soluble in DMSO (10 mg/ml), and 0.1N HCl (5 mg/ml). Insoluble in water, and ethanol.

Storage :

Desiccate at 4° C

Melting Point :

284-286° C

Refractive Index :

n²⁰_D 1.63 (Predicted)

IC50 :

Adenylate cyclase: EC₅₀50 = 71 nM (rat); Zinc finger protein mex-5: EC₅₀50 = 23.99 µM (Caenorhabditis elegans); Dopamine receptor: IC₅₀ = 34.43 µM (rat); Cytoplasmic zinc-finger protein: EC₅₀50 = 108.55 µM (Caenorhabditis elegans)

Ki Data :

D5DR: K_i= ~0.5 nM; D1DR: K_i= 1 nM; D2DR: K_i= ~150 nM; D4DR: K_i= ~1 µM; D3DR: K_i= ~5 µM

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

WGK Germany :

3

PubChem CID :

147514

MDL Number :

MFCD00069248

SMILES :

C1CNCC(C2=CC(=C(C=C21)O)O)C3=CC=CC=C3.Cl

Download SDS (MSDS)

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Certificate of Analysis

Catalog Number sc-203264

Lot Number

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Rated 5 out of 5 by CJ from Shen Shen, MY. et al. (PubMed 25444866) investigated the effects of D1-D2 heteromer stimulation by the agonist SKF 83959 and its disruption by a selective TAT-D1 peptide on amphetamine-induced locomotor sensitization. They found that the dopamine D1-D2 receptor heteromer exerts a tonic inhibitory effect on the expression of amphetamine-induced locomotor sensitization. -SCBT Publication Review

Date published: 2015-07-14

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