SKF 38393 hydrochlorideA benzazepine selective agonist of D1DR

SKF 38393 hydrochloride (CAS 62717-42-4)

SKF 38393 hydrochloride | CAS 62717-42-4 is rated 5.0 out of 5 by 1.
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Synonym: (±)-1-Phenyl-2,3,4,5-tetrahydro-(1H)-3-benzazepine-7,8- diol hydrobromide
Application: A benzazepine selective agonist of D1DR
CAS Number: 62717-42-4
Purity: ≥97%
Molecular Weight: 291.77
Molecular Formula: C16H17NO2•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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SKF 38393 hydrochloride is a benzazepine selective agonist of the D1DR (dopamine D1 receptor). Agonism of the D1DR by SKF 38393 is correlated to induced desynchronization of electroencephalographic activity in rats. SKF 38393 is also reported to demonstrate agonism of the serotonin SR-2C (5-HT1C receptor). SKF 38393 HCl is an activator of D5DR.


References

1. Ongini, E., et al. 1985. Life Sci. 37: 2327-2333. PMID: 3877855
2. Briggs, C.A., et al. 1991. Br. J. Pharmacol. 104: 1038-1044. PMID: 1687364
3. Katz, J.L. and Witkin, J.M. 1992. Psychopharmacology. 107: 217-220. PMID: 1352052

Physical State :
Solid
Solubility :
Soluble in DMSO (10 mg/ml), and 0.1N HCl (5 mg/ml). Insoluble in water, and ethanol.
Storage :
Desiccate at 4° C
Melting Point :
284-286° C
Refractive Index :
n20D 1.63 (Predicted)
IC50 :
Adenylate cyclase: EC5050 = 71 nM (rat); Zinc finger protein mex-5: EC5050 = 23.99 µM (Caenorhabditis elegans); Dopamine receptor: IC50 = 34.43 µM (rat); Cytoplasmic zinc-finger protein: EC5050 = 108.55 µM (Caenorhabditis elegans)
Ki Data :
D5DR: Ki= ~0.5 nM; D1DR: Ki= 1 nM; D2DR: Ki= ~150 nM; D4DR: Ki= ~1 µM; D3DR: Ki= ~5 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
147514
MDL Number :
MFCD00069248
SMILES :
C1CNCC(C2=CC(=C(C=C21)O)O)C3=CC=CC=C3.Cl

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Shen Shen, MY. et al. (PubMed 25444866) investigated the effects of D1-D2 heteromer stimulation by the agonist SKF 83959 and its disruption by a selective TAT-D1 peptide on amphetamine-induced locomotor sensitization. They found that the dopamine D1-D2 receptor heteromer exerts a tonic inhibitory effect on the expression of amphetamine-induced locomotor sensitization. -SCBT Publication Review
Date published: 2015-07-14
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